Figure 1.

Summary of current pre-neoplastic states and myeloid neoplasms. Pre-neoplastic states (in orange: clonal hematopoiesis of indeterminate potential, CHIP; idiopathic cytopenia of undetermined significance, ICUS; and clonal cytopenias of undetermined significance; CCUS) are classified primarily based on the presence of clonality (acquired DNA variants or chromosomal aberrations), and on the presence of peripheral cytopenias [13,14]. The main categories of myeloid neoplasm (blue) are primarily classified based on blast percentage (morphologically primitive cells, including HSPCs), by the type of cells that proliferate aberrantly, and by the morphology of the myeloid cells [15]. VAF, variant allele frequency; MDS, myelodysplastic syndromes; MPN, myeloproliferative neoplasms; MDS/MPN, overlapping MDS and MPN; AML, acute myeloid leukemia.