α-KGDDs |
Alpha-ketoglutarate- and Fe2+-dependent dioxygenases |
ARCH |
Age-related clonal hematopoiesis |
Arg1
|
Arginase 1 |
AML |
Acute myeloid leukemia |
CCUS |
Clonal cytopenia of undetermined significance |
CH |
Clonal hematopoiesis |
CHIP |
Clonal hematopoiesis of indeterminant potential |
CMML |
Chronic myelomonocytic leukemia |
COPD |
Chronic obstructive pulmonary disease |
DNMT3A |
DNA methyltransferase 3 alpha |
DOT1L |
Disruptor of telomeric silencing 1-like |
GERD |
Gastro-esophageal reflux disease |
HDAC2 |
Histone deacetylase 2 |
HMA |
Hypomethylating agents |
HSC |
Hematopoietic stem cells |
HSPC |
Hematopoietic stem/progenitor cells |
ICUS |
Idiopathic cytopenia of undetermined significance |
IL-1β |
Interleukin 1 beta |
IL-18 |
Interleukin 18 |
IL-6 |
Interleukin 6 |
IL6R
|
Interleukin 6 receptor |
LPS |
Lipopolysaccharides |
MDS |
Myelodysplastic syndromes |
MDS-RS |
MDS with ring sideroblasts |
MDS/MPN |
Myelodysplastic syndromes/myeloproliferative neoplasms |
MPN |
Myeloproliferative neoplasm |
NGS |
Next-generation sequencing |
NLRP3 |
Nod-like receptor family pyrin domain containing 3 |
RARS |
Refractory anemia with ring sideroblasts |
SAM |
S-adenosyl-l-methionine |
TET2 |
Tet methylcytosine dioxygenase 2 |
TNF-α |
Tumour necrosis factor alpha |
VAF |
Variant allele frequency |
5mC |
5-methylcytosine |
5hmC |
5-hydroxymethylcytosine |