MS	Multiple sclerosis
IBD	Inflammatory bowel disease
CD	Crohn’s disease
Th17	Human T helper 17
CNS	Central nervous system
IFN	Interferon
EAE	Experimental autoimmune encephalomyelitis
RRMS	Remittent recurrent multiple sclerosis
HD	Healthy donors
CIS	Clinically isolated syndrome
mAb	Monoclonal antibody
Tregs	Anti-inflammatory regulatory T
S1PPBMCs	Sphingosine-1 phosphate Peripheral blood mononuclear cells
GPR	Global Pattern Recognition
FDR	False discovery rate