Table A1.
Complete differential expression data of genes included in the Human T helper 17 (Th17) 96 StellARray qPCR Array in healthy donors versus RRMS patients.
| Rank | Gene Name | p-Value | GPR Fold Change |
|---|---|---|---|
| 1 | SMAD7 | 0.023116 | −4.121045 |
| 2 | TNF | 0.097984 | −1.975738 |
| 3 | CSF3 | 0.115770 | 3.099492 |
| 4 | S1PR1 | 0.169676 | −1.489735 |
| 5 | CEBPD | 0.173658 | 2.447022 |
| 6 | IL18R1 | 0.181638 | 1.741877 |
| 7 | MMP9 | 0.183453 | 2.454003 |
| 8 | ICAM1 | 0.204162 | −1.397425 |
| 9 | IL10 | 0.217187 | −1.478354 |
| 10 | MAP3K14 | 0.227840 | −1.232434 |
| 12 | IL15 | 0.230006 | 1.914874 |
| 13 | IL12RB2 | 0.230664 | 1.408320 |
| 14 | IL17RC | 0.230917 | −2.236766 |
| 15 | IL22 | 0.236646 | 2.149112 |
| 16 | CCR2 | 0.236910 | 1.298827 |
| 17 | PTGES2 | 0.238409 | 1.286509 |
| 19 | CLEC7A | 0.260678 | 1.849452 |
| 21 | CCR5 | 0.280039 | 1.463742 |
| 22 | IL27 | 0.280070 | 2.076678 |
| 23 | PRKCQ | 0.280210 | −1.203029 |
| 24 | PTGS2 | 0.287147 | −1.292593 |
| 25 | CCL5 | 0.288848 | 1.868512 |
| 30 | STAT5A | 0.302796 | 1.180038 |
| 31 | TGFB1 | 0.303116 | −1.169076 |
| 32 | IL6R | 0.305101 | −1.075965 |
| 33 | S100A9 | 0.310143 | 2.053510 |
| 36 | ITGAL | 0.312514 | −1.163330 |
| 37 | IL1B | 0.317977 | −1.351223 |
| 38 | IL1R1 | 0.323904 | −1.318258 |
| 39 | CD28 | 0.326297 | −1.154887 |
| 40 | S100A8 | 0.326948 | 2.071241 |
| 42 | IL17RE | 0.333320 | 2.006149 |
| 43 | IFNG | 0.337986 | 1.213963 |
| 44 | IL17C | 0.342972 | 1.415405 |
| 45 | FAS | 0.348147 | 1.289762 |
| 46 | CD4 | 0.354280 | −1.157741 |
| 47 | IL18 | 0.368094 | −1.327924 |
| 48 | IL12RB1 | 0.374193 | −1.151614 |
| 49 | MAF | 0.380837 | −1.055353 |
| 50 | LIF | 0.380977 | −3.1015170 |
| 51 | RORC | 0.385640 | 1.290307 |
| 52 | JAK2 | 0.388477 | 1.082868 |
| 53 | IL17D | 0.389396 | −1.094554 |
| 54 | IL23A | 0.392817 | −1.192429 |
| 55 | CXCL2 | 0.400369 | −1.428309 |
| 56 | FOXP3 | 0.409157 | 1.087963 |
| 57 | ICOS | 0.422018 | −1.134658 |
| 58 | IL17RB | 0.430393 | 1.039733 |
| 59 | CSF2 | 0.433523 | 1.478325 |
| 60 | IL23R | 0.444508 | 1.133804 |
| 61 | EOMES | 0.445174 | 1.038471 |
| 62 | CCR4 | 0.446667 | 1.160488 |
| 63 | CCL20 | 0.448723 | −2.306566 |
| 64 | CCR6 | 0.468722 | 1.107297 |
| 65 | SYK | 0.471252 | 1.434643 |
| 66 | ITGAX | 0.482659 | 1.562096 |
| 67 | CD8A | 0.482678 | −1.206777 |
| 68 | SOCS3 | 0.484580 | −1.111256 |
| 69 | LCN2 | 0.502556 | 1.358341 |
| 70 | IL21 | 0.515282 | 1.572404 |
| 71 | IL2 | 0.532927 | 1.719894 |
| 72 | ITGAM | 0.546400 | 1.047556 |
| 73 | FASLG | 0.546997 | 1.224576 |
| 74 | HLX | 0.558206 | 1.118766 |
| 75 | CXCL3 | 0.563145 | 1.062506 |
| 76 | MUC5AC | 0.567032 | 2.128834 |
| 77 | IL13 | 0.568119 | 1.404698 |
| 78 | IL4 | 0.594178 | 1.031688 |
| 79 | CARD9 | 0.599793 | 1.587336 |
| 80 | TBX21 | 0.615106 | 1.006864 |
| 81 | CXCL10 | 0.620610 | 1.085097 |
| 82 | DEFB4 | 0.673370 | −1.204941 |
| 83 | IL17RD | 0.711636 | −2.334528 |
| 84 | GZMB | 0.713332 | 1.303447 |
| 85 | CCL11 | 0.755471 | −1.509432 |
| 87 | MMP3 | NS | −1.328030 |
| 88 | MMP13 | NS | −1.605307 |
| 89 | CCL13 | NS | 1.166980 |
| 90 | CXCL12 | NS | 1.726135 |
| 91 | IL17F | NS | 1.173435 |
| 92 | IL6 | NS | −1.988051 |
| 93 | IL12B | NS | −1.152891 |
| 94 | CRP | NS | −1.287846 |
| 95 | IL17A | NS | −1.526223 |
| 96 | IL25 | NS | 1.342714 |
Genes used for normalization and excluded: HS18, NFATC2, CEBPB, STAT4, IL17RA, TRAF3IP2, GATA3, STAT3, TRAF6, NFKB1, and HS genomic.