Table 1.
Selected miRNAs associated with DR, wet AMD, and ROP.
| Diseases | miRNAs | Effects | miRNA Targets | Reference |
|---|---|---|---|---|
| DR | miR-126 | Downregulated in serum of T1DM and T2DM patients | SPRED-1, PIK3R2, VECAM-1 | [91,92,105,106,107,108] |
| miR-150 | Downregulated in plasma of T1DM with DR | n/a | [109] | |
| miR-155 | Upregulated in blood samples of T2DM patients with DR | TGFB | [110] | |
| miR-200b | Downregulated in serum of patient with DR | ETS-1, VEGF-A | [111,112] | |
| miR-221 | Upregulated in serum of T2DM patients | n/a | [113,114,115,116] | |
| miR-27b | Associated with incidence and progression of T1DM by analyzing serum miRNA | SEMA6A, THBS-1 | [117] | |
| miR-320a | Associated with incidence and progression of T1DM by analyzing serum miRNA | NRP1 | [117] | |
| Wet AMD | Let-7 | Upregulated in blood samples of AMD patients | TIMP-1, TSP-1 | [84,86,118,119,120] |
| miR-126 | Downregulated in blood samples of AMD patients | KDR, SPRED-1, VEGF-A | [89,90,91,92,118,121,122,123] | |
| miR-146 | Upregulated in retinal tissues of AMD patients | IRAK1, TNFA | [124,125] | |
| miR-21 | Downregulated in blood samples of AMD patients | RHOB | [89,118,121,126] | |
| ROP | miR-23a | Upregulated in plasma of ROP patients | ISM1, SEMA6A, SEMA6D, SPRY2 | [97,127] |
| miR-200b | Upregulated in plasma of ROP patients | ETS-1, VEGF-A | [112,127,128]. | |
| miR-27b | Downregulated in plasma of ROP patients | VEGF-B, VEGF-C | [72,127,129,130] | |
| miR-214 | Downregulated in plasma of ROP patients | ANG, HIF1A, QKI | [72,127,131] |
AMD, age-related macular degeneration; DR, diabetics retinopathy; n/a, not applicable; ROP, retinopathy of prematurity; T1DM, Type 1 diabetes mellitus; T2DM, Type 2 diabetes mellitus.