Figure 5.

A. Junctional conductance (Gj), monitored in Xenopus oocyte pairs (Cx38), exposed to 100% CO₂. Oocytes in which CaM expression is inhibited by the injection of antisense oligonucleotides progressively lose uncoupling efficiency (A). The CO₂ effect on Gj is reduced by ~60%, ~76%, ~93% in 24, 48 and 72 h, respectively (A). (B). Gj monitored in oocyte pairs expressing Cx45 during CO₂ exposure. The inhibition of CaM expression greatly reduces the CO₂ sensitivity of Cx45 channels—with 15 min application of CO₂, Gj reversibly drops by only ~17%, while in controls it drops to 0% (B). The Gj rise that precedes the Gj drop is absent with the inhibition of CaM expression (B). (A,B) from References [73,106], respectively.