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. 2020 Jan 12;21(2):485. doi: 10.3390/ijms21020485

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© 2020 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) Cytoplasmic loop (CL) sequences of rat Cx32 and Xenopus Cx38. (B,C) Junctional conductance (Gj) monitored in Xenopus oocyte pairs expressing Cx32, Cx38 or Cx32/38 chimeras. Channels made of Cx32/38CL (Cx32’s CL replaced by that of Cx38) reproduce almost exactly the gating efficiency of Cx38 channels in magnitude and rate (B). Similar results were obtained with channels made of Cx32/38CL2 (Cx32’s CL2 replaced by that of Cx38, C), although Gj recovered faster. Note that CL2 contains the CaM binding site (A). The postulated CL1–CT1 interaction (see text) could explain the faster recovery of Cx32/38CL2 channels (C). B and C adapted from References [55,128], respectively.