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CaM is likely to be anchored to the connexin’s CL2 site by its C-lobe (a). With [Ca2+]i > ~50 nM, the N-lobe would gate the channel by binding hydrophobically and electrostatically to the CL2 (b) or NT (c) domain of the same connexin (trans-domain interaction) or another connexin of the same connexon (trans-subunit interaction).
