Cognitive impairment following doxycycline-induced miR-34a expression. A. On the forced alternation T-maze, a measure of working and reference memory, mice given Doxy were significantly impaired in their ability to successfully win-shift alternate (mean ± SEM percent successful alternations) [t-test: t(14) = 4.719, p < 0.0005]. B. On the spontaneous alternation Y-maze, a measure of working memory, mice given Doxy were significantly impaired in their ability to successfully undergo spontaneous alternation (mean ± SEM percent successful alternations) [t-test: t(12) = 5.845, p < 0.0001]. N = 7–8 mice/group. * p < 0.05.