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. Author manuscript; available in PMC: 2020 Oct 15.
Published in final edited form as: Brain Res. 2019 Jul 8;1721:146327. doi: 10.1016/j.brainres.2019.146327

Fig. 7.

Fig. 7.

Downregulation of ADAM-10 in doxycycline-induced miR-34a expression in brain regions of transgenic mice. A. Representative western blots of Aβ expression (ADAM-10 antibody) among mice given Doxy vs No Doxy controls in the entorhinal cortex (EC), hippocampus (HI), prefrontal cortex (PFC), and thalamus (TH). B. Densitometric quantification of relative protein levels (ADAM10/GAPDH) is shown in the bar graph. Data are mean ± SD, and the results shown are representative of three animals in each group. The significant Treatment main effect [F(1,4) = 820.6, p < 0.0001] was followed up with Bonferroni-corrected multiple comparisons of the effect of Treatment in each brain region, **** p < 0.0001. Immunohistology of anti-β-amyloid antibody clone 6E10 in the cortex (C) and hippocampus (D) of mice given Doxy vs No Doxy controls. Scale bars 200 μm. E. High magnification of intracellular localization of anti-β-amyloid antibody clone 6E10 staining in the hippocampus. Scale bar 100 μm.