Figure 16.

A) Schematics of drug loaded SELP liquid embolic agent. B) Illustration of SELP-815 K structure. In vitro drug release profiles from 12% SELP-815 K loaded with doxorubicin and sorafenib powders. Relative release rates of C) Doxorubicin and D) Sorafenib from single drug loaded gels (either 25 mg/mL or 50 mg/mL) or from dual drug loaded gel at 25 mg/mL loading (per drug). Statistical significance between single drug loaded versus dual drug loaded gels (*); single drug loaded 25 mg/mL versus single drug loaded 50 mg/mL gels (+);single drug loaded 50 mg/mL gels and the dual drug loaded gels (•). Statistical significance is reported as p < 0.05, highly significant as p < 0.01 and very highly significant as p < 0.001. Figure components adapted and reproduced with permission.^{[271, 272b]} Copyright 2016, American Chemical Society and 2015, Elsevier.