Table 7.
Human Study: Geometric Mean (CV%) Values of key pharmacokinetic parameters for MET 2
| 300-mg GET 73 | Experiment 3 (300-mg GET 73 once) | Experiment 4 (300-mg GET 73 trice) | ||
|---|---|---|---|---|
| Intervention | NALC a | ALC a | NALC a | ALC a |
| n | 13 | 12 | 11 | 10 |
| Cmax(ng/mL) | 5120 (22.2) | 3460 (22.8) | 5890 (21.8) | 4440 (27.6) |
| tmax (h)b | 2.00 (0.50–4.00) | 1.50 (0.50–3.00) | 8.00 (0.50–16.00) | 9.00 (3.00–16.00) |
| tlag (h)b | 0.00 (0.00–0.25) | 0.00 (0.00–0.00) | 0.00 (0.00–0.00) | 0.00 (0.00–0.00) |
| AUClast(h.ng/mL) | 15660 (16.1) | 13090 (17.4) | 51230 (21.9) | 49070 (22.) |
| AUCinf(h.ng/mL) | 15750 (16.1) | 13180 (17.2) | 51370 (21.7) | 49210 (22.7) |
| t1/2 (h) | 1.29 (24.2) | 1.29 (13.2) | 1.47 (20.2) | 1.61 (26.5) |
a
NALC: soda with No Alcohol, ALC: soda with Alcohol
b
Result s reported