. Author manuscript; available in PMC: 2020 Feb 12.

Published in final edited form as: J Psychopharmacol. 2018 Jan 23;32(2):163–173. doi: 10.1177/0269881117746904

TABLE 8 –

Human Study: Bioavailability Analysis of MET 2

Pharmacokinetic Parameter	Study Experiment	N	NALC ^a,b	ALC ^a,b	NALC/ALC ^c	NALC/ALC90% CI ^d
AUC_last (h.ng/mL)	1	12	15613	13178	1.18	(1.10, 1.27)
AUC_last (h.ng/mL)	2	10	51598	49421	1.04	(0.97, 1.13)

AUC_∞ (h.ng/mL)	1	12	15519	13093	1.19	(1.10, 1.27)
AUC_∞ (h.ng/mL)	2	10	51459	49282	1.04	(0.96, 1.13)

C_max (ng/mL)	1	12	5136	3462	1.48	(1.32, 1.67)
C_max (ng/mL)	2	10	5722	4401	1.30	(1.14, 1.48)

Results reported as mean and lower to upper 95% (CI)

NALC: soda with No Alcohol, ALC: soda with Alcohol

Adjusted geometrics mean from ANOVA model

Ratio of adjusted geometric mean

Confidence interval for the ratio adjusted geometric means