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. 2020 Feb 11;9:F1000 Faculty Rev-105. [Version 1] doi: 10.12688/f1000research.20904.1

Figure 1. Differentiation of progenitor cells is a highly choreographed process.

Figure 1.

( A) A diagram depicts an epigenetic landscape of cellular fate decision-making during oligodendrocyte development from neural progenitor cells. Beginning with neural progenitors, cell differentiation occurs along multiple potential pathways with cells taking on neuronal, astrocyte, or oligodendrocyte lineages. This differentiation from a common progenitor population involves the fine tuning of gene expression and turning on and off of lineage-specific genes and their epigenetic regulators. ( B) Many modulators of gene expression are through epigenetic mechanisms, which alter gene expression on the basis of local environmental factors. These mediators include covalent modifications to DNA or histones, RNA-mediated regulation of gene expression, or the enzymes responsible for mediating the effects of these modifications. BRG1, Brahma-related 1; CHD, chromodomain helicase DNA-binding; cOPC, committed oligodendrocyte progenitor cell; DNMT, DNA methyltransferase; HAT, histone acetyltransferase; HDAC, histone deacetylase; OL, oligodendrocyte; pri-OPC, primitive oligodendrocyte progenitor cell; TET, ten-eleven translocation.