Figure 2. Global expression levels of key epigenetic regulators during oligodendrocyte differentiation from progenitor cells.
Epigenetic modifiers, including ATP-dependent chromatin remodelers, histone acetyltransferases and deacetylases, histone methyltransferases, and demethylases, are critical components of the differentiation process, according to the data from a bulk RNA sequencing dataset 92. The change of epigenetic modifiers across oligodendrocyte differentiation is depicted. The global changes of expression levels in the epigenetic modifications themselves are based on the studies 41, 44, 62, 63, 66, 93. OPC, oligodendrocyte progenitor cell.