Table E5.
HRs (99% CIs) for association between atopic eczema disease severity and fracture for all fracture types
| Number | Events/person-years at risk | Minimally adjusted |
Adjusted for IMD, asthma, and calendar period |
Additionally adjusted for potential mediators (BMI, harmful alcohol use, smoking, and oral glucocorticoids) |
|||
|---|---|---|---|---|---|---|---|
| HR∗ (99% CI) | HR∗ (99% CI) | No. | Events/person-years at risk | HR∗ (99% CI) | |||
| Hip fractures | |||||||
| Without atopic eczema | 2,569,015 | 30,592/14,849,062 | 1.0 (reference) | 1.0 (reference) | 1,839,065 | 23,041/11,516,122 | 1.0 (reference) |
| Mild atopic eczema | 392,499 | 3,948/2,029,502 | 1.05 (1.0-1.11) | 1.04 (0.98-1.10) | 325,586 | 3,392/1,781,494 | 1.01 (0.95-1.07) |
| Moderate atopic eczema | 186,158 | 3,256/1,110,516 | 1.14 (1.07-1.21) | 1.12 (1.06-1.19) | 163,921 | 2,864/1,015,951 | 1.11 (1.03-1.18) |
| Severe atopic eczema | 34,378 | 618/186,187 | 1.53 (1.32-1.77) | 1.50 (1.30-1.74) | 29,515 | 552/186,547 | 1.48 (1.26-1.74) |
| Pelvic fractures | |||||||
| Without atopic eczema | 2,569,024 | 7,337/14,911,177 | 1.0 (reference) | 1.0 (reference) | 1,839,071 | 5,590/11,565,470 | 1.0 (reference) |
| Mild atopic eczema | 392,845 | 1,007/2,037,740 | 1.06 (0.95-1.18) | 1.05 (0.94-1.17) | 325,913 | 880/1,788,809 | 0.98 (0.87-1.11) |
| Moderate atopic eczema | 186,649 | 752/611,986 | 1.11 (0.98-1.26) | 1.10 (0.97-1.24) | 164,349 | 672/1,022,940 | 1.10 (0.96-1.27) |
| Severe atopic eczema | 34,577 | 164/103,941 | 1.71 (1.29-2.26) | 1.66 (1.26-2.20) | 29,664 | 146/169,964 | 1.49 (1.10-2.03) |
| Spinal fractures | |||||||
| Without atopic eczema | 2,569,023 | 8,716/14,904,064 | 1.0 (reference) | 1.0 (reference) | 1,839,072 | 7,011/11,559,317 | 1.0 (reference) |
| Mild atopic eczema | 392,773 | 1,203/2,036,459 | 1.08 (0.98-1.19) | 1.06 (0.96-1.17) | 325,852 | 1,087/1,787,605 | 1.02 (0.92-1.13) |
| Moderate atopic eczema | 186,586 | 993/1,117,173 | 1.27 (1.14-1.41) | 1.22 (1.10-1.36) | 164,286 | 930/1,021,841 | 1.18 (1.05-1.32) |
| Severe atopic eczema | 34,533 | 243/187,419 | 2.18 (1.73-2.75) | 2.09 (1.66-2.65) | 29,639 | 228/169,598 | 1.98 (1.54-2.55) |
| Wrist fractures | |||||||
| Without atopic eczema | 2,569,021 | 25,068/14,818,020 | 1.0 (reference) | 1.0 (reference) | 1,839,071 | 20,384/11,487,169 | 1.0 (reference) |
| Mild atopic eczema | 392,260 | 3,520/2,023,035 | 1.07 (1.02-1.13) | 1.05 (1.00-1.11) | 325,379 | 3,162/1,775,172 | 1.04 (0.98-1.10) |
| Moderate atopic eczema | 186,034 | 2,284/1,107,864 | 1.10 (1.03-1.17) | 1.08 (1.01-1.15) | 163,770 | 2,105/1,013,070 | 1.07 (0.99-1.15) |
| Severe atopic eczema | 34,432 | 406/185,970 | 1.22 (1.04-1.44) | 1.18 (1.00-1.39) | 29,546 | 374/168,230 | 1.18 (0.99-1.41) |
| Proximal humeral fractures | |||||||
| Without atopic eczema | 2,569,024 | 7,337/14,911,177 | 1.0 (reference) | 1.0 (reference) | 1,839,075 | 5,218/11,563,988 | 1.0 (reference) |
| Mild atopic eczema | 392,846 | 813/2,037,888 | 0.92 (0.82-1.03) | 0.90 (0.81-1.01) | 325,933 | 773/1,788,900 | 1.0 (0.88-1.12) |
| Moderate atopic eczema | 186,657 | 629/1,118,300 | 0.99 (0.87-1.13) | 0.98 (0.86-1.11) | 164,354 | 602/1,022,750 | 1.04 (0.90-1.19) |
| Severe atopic eczema | 34,560 | 116/103,957 | 1.29 (0.95-1.77) | 1.27 (0.93-1.73) | 29,675 | 112/170,017 | 1.29 (0.93-1.79) |
| Any fracture | |||||||
| Without atopic eczema | 2,568,889 | 179,471/14,146,660 | 1.0 (reference) | 1.0 (reference) | 1,838,979 | 135,663/10,967,230 | 1.0 (reference) |
| Mild atopic eczema | 387,988 | 25,743/1,914,235 | 1.08 (1.06-1.11) | 1.06 (1.04-1.08) | 321,523 | 21,755/1,680,248 | 1.03 (1.01-1.06) |
| Moderate atopic eczema | 181,742 | 15,883/1,033,021 | 1.17 (1.14-1.20) | 1.14 (1.11-1.17) | 159,818 | 14,263/944,385 | 1.11 (1.08-1.14) |
| Severe atopic eczema | 33190 | 2,919/171,673 | 1.33 (1.25-1.41) | 1.27 (1.20-1.36) | 28,428 | 2,594/155,271) | 1.22 (1.14-1.30) |
∗
Estimated HRs from Cox regression with current age as the underlying timescale stratified by matched set (matched on age at cohort entry, sex, general practice, and date at cohort entry). All models fitted to individuals with complete data for all variables included in each model and from valid matched sets, including 1 individual with atopic eczema and at least 1 individual without atopic eczema. All models implicitly adjusted for sex, date at cohort entry, and practice (because of stratification by matched set) and age (because of underlying timescale).