Table 4.

Univariate and multivariate analysis for the association between clinical characteristics and progression-free survival

Variable	Univariate		Multivariate
	HR(95% CI)	P value	HR(95% CI)	P value
Age (year)
<50	1
≥ 50	1.352(0.980–1.866)	0.066
FIGO stage
I-II	1		1
III-IV	2.577(1.717–3.868)	<0.001	3.337(2.049–5.436)	<0.001
Histological grade
Low	1
High	1.250(0.852–1.835)	0.254
Lymph node invasion
Negative	1		1
Positive	1.608(1.107–2.336)	0.013	1.069(0.692–1.653)	0.763
Tumor residual (cm)
Optimal(≤1)	1		1
Sub-optimal(>1)	1.732(1.204–2.466)	0.003	1.314(0.864–1.997)	0.202
CA125 level (U/mL)
≤ 35	1		1
>35	3.156(1.468–6.785)	0.003	1.454(0.621–3.407)	0.388
Severity of CIN
Mild versus Absence	0.241(0.139–0.419)	<0.001	0.593(0.322–1.092)	0.093
Sever versus Absence	0.275(0.150–0.506)	<0.001	0.615(0.318–1.888)	0.148
Mild versus Sever	0.876(0.598–1.282)	0.495	0.965(0.649–1.435)	0.860
Timing of CIN
Early onset	1		1
Non-early onset	3.803(2.687–5.383)	<0.001	5.098(3.389–7.669)	<0.001