Table 5.

Univariate and multivariate analysis for the association between clinical characteristics and overall survival

Variable	Univariate		Multivariate
	HR(95% CI)	P value	HR(95% CI)	P value
Age (year)
<50	1		1
≥ 50	1.598(1.147–2.226)	0.006	1.264(0.887–1.802)	0.195
FIGO stage
I-II	1		1
III-IV	3.794(2.454–5.864)	<0.001	5.004(2.951–8.485)	<0.001
Histological grade
Low	1		1.
High	1.613(1.073–2.425)	0.022	1.302(0.823–2.059)	0.259
Lymph node invasion
Negative	1		1
Positive	2.583(1.759–3.795)	<0.001	1.042(0.642–1.694)	0.867
Tumor residual (cm)
Optimal(≤1)	1		1
Sub-optimal(>1)	4.183(2.845–6.149)	<0.001	3.182(1.970–5.140)	<0.001
CA125 level (U/mL)
≤ 35	1		1
>35	4.360(1.779–10.681)	0.001	1.142(0.411–3.168)	0.799
Severity of CIN
Mild versus Absence	0.224(0.128–0.393)	<0.001	0.512(0.269–0.975)	0.042
Sever versus Absence	0.211(0.112–0.397)	<0.001	0.493(0.246–0.989)	0.046
Mild versus Sever	1.060(0.708–1.588)	0.776	1.039(0.671–1.608)	0.864
Timing of CIN
Early onset	1		1
Non-early onset	3.696(2.593–5.268)	<0.001	6.713(4.295–10.492)	<0.001