Table 1.

Characteristics of PML patients

	HIV	Risk factor	CSF composition	CD4/CD8 ratio (blood)	CSF JCPyV-DNA IU/mL	NCCR organization
Case 1	negative	natalizumab	glucose: 54 mg/dl proteins: 569 mg/L cell count: 5 cells/μl	0.45	1.62 × 106	A–B*–C–E–F
Case 2	negative	dimethyl fumarate	glucose: 56 mg/dl proteins: 35 mg/L cell count: 2 cells/μl	5.36	4.9 × 105	A–B–C–(D)–E–F
Case 3	positive	HIV infection	glucose: 76 mg/dl proteins: 413 mg/L cell count: 2 cells/μl	0.10	8.97 × 105	A-B-(C)-(E)-(F)-(B)-(C)-(E)-F*
Case 4	positive	HIV infection	glucose: 43 mg/dl proteins: 46 mg/L cell count: 2 cells/μl	0.11	2.34 × 106	A–C*–E*–F*

Letter in brackets indicates the presence of a rearranged block. Asterisk (*) indicates a single nucleotide polymorphism. CSF cerebrospinal fluid, JCPyV JC polyomavirus, NCCR non-coding control region