Fig. 2.

Properties of fetal, maternal, and microbial cfDNA in amniotic fluid. a Comparison of IL-6 levels to the fraction of reads derived from the fetus. b Fragment length profile of chromosome 21 derived cfDNA in amniotic fluid (n = 40). c Comparison of clinically measured IL-6 levels to the difference in the median fragment length for cfDNA originating from the X and Y chromosomes. Colors for a and c correspond to clinical status. d Bacterial species and viral families detected by cfDNA metagenomic sequencing and LBBC. Crosshairs indicate bacteria identified by 16S sequencing. Chor./−, chorioamnionitis, no detectable microorganisms; Chor./+, chorioamnionitis, detectable microorganisms