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Model schematic. Treatment with TMZ causes DNA methylation, leading to cell arrest. TMZ-induced methylation sites are N7-meG, N3-meA (repaired by the APNG-mediated BER pathway) and O6-meG (repaired by the MGMT pathway). If DNA damage repair is successful, the cell recovers to the proliferating pool, or undergoes apoptosis otherwise. (Online version in colour.)
