Table 1.

Description of treatment strategies. Standard and optimal treatment strategies identified by GBM cell phenotype. Note that the specific daily dose of TMZ varies between strategies. Here, SMI stands for small molecule inhibitor. Standard TMZ refers to a TMZ protocol as it is typically administered in the clinic [43]. Optimal TMZ refers to an alternating high/low dosage schedule with no APNG/MGMT inhibitors administered.

		treatment strategy	TMZ	SMI APNG	SMI MGMT
		standard TMZ	constant dose days 1–5	none	none
			rest days 6–28
		optimal TMZ	high dose days 1, 3 and 5	none	none
			low dose days 2 and 4
			rest days 6–28
cell phenotype	APNG−/MGMT−	A	high dose days 1, 3 and 5	days 1–5	days 1 and 5
			low dose days 2 and 4
			rest days 6–28
	APNG+/MGMT−	B	high dose days 1, 3 and 5	days 1–5	days 2, 3 and 4
			low dose days 2 and 4
			rest days 6–28
	APNG−/MGMT+	C	high dose days 1, 3 and 5	days 1–5	days 1, 2, 3 and 4
			low dose days 2 and 4
			rest days 6–28
	APNG+/MGMT+	D	high dose days 1, 3 and 5	days 1–5	days 1–5
			low dose days 2 and 4
			rest days 6–28