. 2020 Feb 1;388:114872. doi: 10.1016/j.taap.2019.114872

Table 1.

Changes in body and tissue weights in Wistar rats following daily oral gavage with acetamide.

Dose (mg/kg/day)	Terminal fasting body weight (g)	Liver weight (g)	Relative liver weight (% Body Weight)
Experiment A
Males, day 8
0	314.9 ± 8.2	9.77 ± 0.37	3.10 ± 0.09
30	316.3 ± 10.0	10.17 ± 0.26	3.22 ± 0.06
100	313.7 ± 9.5	9.48 ± 0.35	3.02 ± 0.07
300	313.0 ± 9.3	9.71 ± 0.49	3.10 ± 0.10
1000	293.7 ± 6.5	▼7.29 ± 0.24^a	▼2.48 ± 0.08^a

Experiment B
Males, day 8
0	294.3 ± 13.5	9.00 ± 0.50	3.06 ± 0.09
300	298.7 ± 8.1	9.23 ± 0.33	3.10 ± 0.12
500	301.9 ± 8.9	8.70 ± 0.41	2.88 ± 0.08
750	301.3 ± 6.7	9.00 ± 0.33	2.99 ± 0.07
1000	305.4 ± 10.1	8.98 ± 0.37	2.94 ± 0.07
1500	295.7 ± 6.3	8.04 ± 0.31	▼2.72 ± 0.06^a
Males, day 29
0	389.8 ± 9.1	11.23 ± 0.57	2.88 ± 0.10
300	384.7 ± 14.0	11.44 ± 0.45	2.98 ± 0.09
500	375.6 ± 12.4	10.76 ± 0.52	2.86 ± 0.09
750	379.2 ± 14.9	10.67 ± 0.51	2.81 ± 0.07
1000	383.8 ± 14.1	9.86 ± 0.43	2.57 ± 0.09
1500	362.3 ± 10.5	9.89 ± 0.34	2.73 ± 0.09
Females, day 8
0	207.6 ± 4.0	6.05 ± 0.27	2.91 ± 0.11
300	210.5 ± 5.7	6.18 ± 0.28	2.93 ± 0.09
500	207.3 ± 4.3	5.69 ± 0.27	2.74 ± 0.09
750	204.3 ± 4.1	5.69 ± 0.18	2.78 ± 0.04
1000	201.0 ± 4.4	5.59 ± 0.30	2.78 ± 0.12
1500	202.5 ± 5.1	5.92 ± 0.28	2.92 ± 0.08
Females, day 29
0	245.2 ± 9.7	6.46 ± 0.34	2.63 ± 0.07
300	236.2 ± 5.4	6.35 ± 0.14	2.69 ± 0.07
500	235.8 ± 9.7	6.27 ± 0.26	2.66 ± 0.05
750	234.5 ± 6.4	5.90 ± 0.20	2.52 ± 0.07
1000	231.8 ± 7.1	5.67 ± 0.17	2.45 ± 0.06
1500	224.8 ± 5.1	5.91 ± 0.10	2.63 ± 0.05

Significant difference (P ≤ .05) compared to vehicle control animals determined by one-way ANOVA and Dunnett's post-hoc test using Provantis.