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Human ARAF, BRAF and CRAF sequences are aligned and identically conserved residues are shaded red. Secondary structure elements are indicated above the alignment. Symbols above the alignment indicate residues that in the autoinhibited structure lie in the interface with MEK1 (blue circles), the CRD/14-3-3 interface (violet squares), the CRD/kinase domain interface (blue triangles), and the 14-3-3/kinase domain interface (yellow stars).
