Table 3.

Predictors of bronchodilator reversibility in children with asthma enrolled in SARP I-II

a. Predictors of 12% relative bronchodilator reversibility in all children with asthma (n=220)
Variables	Odds ratio	95% CI	p value
Exposure to second-hand smoke	2.81	1.23 to 6.43	0.014
Severe asthma	2.08	1.05 to 4.13	0.036
Pre-bronchodilator FEV1 % predicted	0.91	0.88 to 0.94	<0.001

b. Predictors of 12% relative bronchodilator reversibility in all children with asthma, including exhaled nitric oxide (n=200)
Variables	Odds ratio	95% CI	p value
Log FeNO*	1.97	1.35 to 2.87	0.0005
Pre-bronchodilator FEV1 % predicted	0.91	0.88 to 0.94	<0.001

c. Predictors of 12% relative bronchodilator reversibility in children with severe asthma, including exhaled nitric oxide (n=117)
Variables	Odds ratio	95% CI	p value
Log FeNO*	3.045	1.624 to 5.709	0.0005
Pre-bronchodilator FEV1 % predicted	0.91	0.87 to 0.95	<0.001

^*offline and online eNO combined

Variables included: severe asthma, asthma duration, age of asthma onset, #positive skin tests, pre-BD FEV₁ (L), pre-BD FEV₁% predicted, second-hand smoke exposure, % blood eosinophils, IgE, 3+OCS burst in last year, ER/Urgent care in past year, admission in past year

^*offline and online eNO combined

Variables included: severe asthma, asthma duration, age of asthma onset, #positive skin tests, pre-BD FEV₁ (L), pre-BD FEV₁% predicted, second-hand smoke exposure, % blood eosinophils, IgE, 3+OCS burst in last year, ER/Urgent care in past year, admission in past year, FeNO

^*offline and online eNO combined

Variables included: asthma duration, age at enrollment, pre-BD FEV₁ (L), pre-BD FEV₁% predicted, second-hand smoke exposure, % blood eosinophils, ICU admission, FeNO