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Molecular mechanisms involved in PLAG1 regulation in OC cells. PLAG1 activates the IGF2 signaling pathway in OC by upregulating IGF2, IGF1R and IRS1 and by accelerating migration and invasion, as well as repressing chemosensitivity of OC cells. PLAG1, pleomorphic adenoma gene 1; IGF2, insulin-like growth factor-2; IGF1R, insulin-like growth factor 1 receptor; IRS1, insulin receptor substrate 1; OC, ovarian cancer.
