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. 2019 Dec 18;30(2):133–145. doi: 10.1038/s41422-019-0264-2

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© IBCB, SIBS, CAS 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Large-scale screening and potential applications of DM1 mice. a Diagram of large-scale screening for small molecules that can promote differentiation of DM1 MuSCs. b Molecular structure of T5381948. c Images show that T5381948 could specifically improve the in vitro differentiation of DSM-TKO MuSCs. Scale bars, 200 μm. Unpaired Student’s t-test; ***P < 0.001; NS, no significant differences. d Overview of the generation and applications of DM1 mouse model with quadruple heterozygous mutations