Table 2.
Outcome | Overall | Prednisolone | Tacrolimus | P Value | ||||||
---|---|---|---|---|---|---|---|---|---|---|
n | Cohort | Percentage | n | Cohort | Percentage | n | Cohort | Percentage | ||
Primary outcome | ||||||||||
Complete remission by 8 wk | 38 | 50 | 76 | 21 | 25 | 84 | 17 | 25 | 68 | 0.32 (0.54) |
Secondary outcomes | ||||||||||
Complete remission by 16 wk | 42 | 50 | 84 | 23 | 25 | 92 | 19 | 25 | 76 | 0.25 (0.54) |
Complete remission by 26 wk | 45 | 50 | 90 | 23 | 25 | 92 | 22 | 25 | 88 | 0.99 (1.00) |
Any relapse after complete remission | 33 | 45 | 73 | 17 | 23 | 74 | 16 | 22 | 73 | 0.99 |
Change in serum creatinine at 12 mo, mg/dl | 50 | Median = 0.02 Range = −1.25 to 0.64 |
25 | Median = 0.01 Range = −1.25 to 0.20 |
25 | Median = 0.02 Range =−0.47 to 0.64 |
0.16 | |||
Exploratory outcomes | ||||||||||
Complete remission by 4 wk | 22 | 50 | 44 | 16 | 25 | 64 | 6 | 25 | 24 | 0.01 (0.05) |
Complete or partial remission by 4 wk | 39 | 50 | 78 | 20 | 25 | 80 | 19 | 25 | 76 | 0.99 (1.00) |
Failed to achieve complete remission | 5 | 50 | 10 | 2 | 25 | 8 | 3 | 25 | 12 | 0.99 |
Adjusted P values for multiple analyses are shown in parentheses.