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. 2020 Jan 23;15(2):200–208. doi: 10.2215/CJN.06600619

Table 2.

Effect of the sodium bicarbonate intervention on acid-base indices

Measurement Serum Total CO2 (meq/L) Urinary NH4+ (meq/d) Urinary TA (meq/d) Urinary pH
Sodium Bicarbonate Placebo Sodium Bicarbonate Placebo Sodium Bicarbonate Placebo Sodium Bicarbonate Placebo
Within-group Δ from baseline
 At mo 3 1.3 (0.4 to 2.1) 0.1 (−0.8 to 0.9) −8 (−13 to −3) −1 (−5 to 4) −10 (−15 to −5) 2 (−3 to 7) 0.6 (0.5 to 0.8) 0.0 (−0.2 to 0.1)
 At mo 6 1.0 (0.3 to 1.8) −0.2 (−0.9 to 0.6) −5 (−11 to 1) −1 (−7 to 5) −11 (−16 to −5) 0 (−5 to 6) 0.7 (0.6 to 0.9) 0.1 (−0.1 to 0.3)
 Over mo 3 and 6 1.2 (0.5 to 1.9) 0.0 (−0.7 to 0.7) −6 (−11 to −2) −1 (−6 to 3) −10 (−15 to −6) 1 (−4 to 6) 0.7 (0.5 to 0.8) 0.0 (−0.1 to 0.2)
Sodium Bicarbonate versus Placebo Sodium Bicarbonate versus Placebo Sodium Bicarbonate versus Placebo Sodium Bicarbonate versus Placebo
Difference in change from baseline
 At mo 3 1.2 (0.0 to 2.4) −7 (−13 to −1) −12 (−19 to −5) 0.7 (0.5 to 0.8)
 At mo 6 1.2 (0.1 to 2.2) −4 (−12 to 4) −11 (−19 to −3) 0.6 (0.4 to 0.8)
 Over mo 3 and 6 1.2 (0.3 to 2.1) −5 (−11 to 0) −11 (−18 to −5) 0.6 (0.5 to 0.8)

Data are shown as mean (95% confidence intervals). Positive values for difference in change indicate that the change was greater in the sodium bicarbonate group. TA, titratable acid.