Table 4.
Effects of the sodium bicarbonate intervention on exploratory outcomes (kidney function) and BP, total body weight, and serum potassium
| Variable | Difference in Change from Baseline to mo 3 (95% CI) | Difference in Change from Baseline to mo 6 (95% CI) | Difference in Change from Baseline to mo 3 and 6 (95% CI) |
|---|---|---|---|
| eGFR, ml/min per 1.73 m2 | 2.8 (−1.2 to 6.8) | 4.0 (−0.5 to 8.5) | 3.4 (−0.1 to 6.8) |
| BUN, mg/dl | −6 (−9 to −2) | −6 (−10 to −1) | −6 (−9 to −2) |
| Creatinine clearance, ml/min | 0 (−11 to 11) | 5 (−9 to 20) | 3 (−8 to 13) |
| 24-h urinary creatinine, mg/d | −103 (−381 to 175) | −6 (−320 to 308) | −55 (−290 to 180) |
| Systolic BP, mm Hg | 6 (0 to 13) | 2 (−5 to 9) | 4 (−2 to 10) |
| Diastolic BP, mm Hg | 2 (−2 to 7) | −1 (−4 to 4) | 1 (−2 to 5) |
| Total body wt, kg | −1.3 (−3.0 to 0.5) | −0.9 (−3.0 to 1.2) | −1.1 (−2.8 to 0.6) |
| Serum potassium, meq/L | −0.1 (−0.2 to 0.1) | −0.1 (−0.3 to 0.1) | −0.1 (−0.2 to 0.1) |
Positive values for difference in change indicate that the change was greater in the sodium bicarbonate group. 95% CI, 95% confidence interval.