Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jan 10;45(3):731–742. doi: 10.3892/ijmm.2020.4464

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Jiang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PMC Copyright notice

Ligustrazine inhibits the upregulation of NOD2 following I/R in a rat model. (A) Relative quantitation of mRNA levels of NOD2 by RT-qPCR analysis in kidneys from different groups. (B) Representative western blots and summarized data showing the protein levels of NOD2 in kidneys from different groups. (C) Representative photomicrographs of NOD2 IHC staining in the tubules and glomeruli of kidneys from different groups. Bars, 100 µm (magnification, ×200). (D) Quantitative analysis of IHC staining showing increased expression of NOD2 in the tubules and glomeruli of rats after I/R, which was significantly decreased with ligustrazine administration. ^*P<0.05 vs. sham-operated rats (n=9), ^#P<0.05 vs. I/R rats (n=9). Ligu, ligustrazine; I/R, ischemia/reperfusion; NOD2, nucleotide-binding oligomerization domain-containing 2; IHC, immunohistochemistry.