Weekly body weight alterations and food consumption in the six subject groups. (A) The graph presents comparisons of body weight in the WT-ND, WT-HFD, WT-HFD-ACE, WT-HFD-SHAM, KO-ND and KO-HFD groups. Significant body weight increases in the WT-HFD, WT-HFD-ACE and WT-HFD-SHAM groups compared to the WT-ND group and both TRPV1 KO mouse groups were observed. *P<0.05. There was significant body weight decease in the WT-HFD-ACE group compared to the WT-HFD group and WT-HFD-SHAM group. *P<0.05. (B) The graph presents comparisons in food consumption in the WT-ND, WT-HFD, WT-HFD-ACE, WT-HFD-SHAM, KO-ND and KO-HFD groups. Significant increases of food intake in all normal mice chow, WT-ND and KO-ND groups compared to the HFD-fed mouse groups were observed. *P<0.05. A significant difference in food consumption was also observed for the KO-HFD group when compared with the WT-HFD, WT-HFD-ACE and WT-HFD-SHAM groups. There was significant decrease of food intake in the WT-HFD-ACE group compared with the WT-HFD group in Week 8. *P<0.05. WT, wild-type; ND, normal diet; HFD, high-fat diet; ACE, acupoint catgut embedding; KO, knockout.