Table 1:
Characteristics of Patients in the primary analysis
| Participant Characteristics | Standard Blood Pressure N=4193 |
Intensive Blood Pressure N=4187 |
|---|---|---|
| Gender, Male (%) | 2742 (65.4) | 2696 (64.4) |
| Age, years, median interquartile range (IQR) | 67 (61, 76) | 67 (61, 76) |
| Race/Ethnicity (%) | ||
| Black | 1296 (30.9) | 1253 (29.9) |
| White | 2773 (66.1) | 2787 (66.6) |
| Ethnicity (%) Hispanic | 435 (10.4) | 455 (10.9) |
| Fasting Glucose mg/dL, median (IQR) | 97 (91, 104) | 97 (90,104) |
| Fasting Glucose mmol/L, median (IQR) | 5.38 (5.05, 5.77) | 5.38 (5.00, 5.77) |
| Systolic Blood pressure mm/Hg, median (IQR) | 139 (130, 149) | 138 (129, 149) |
| Diastolic Blood pressure mm/Hg, median (IQR) | 78 (70, 86) | 78 (70, 86) |
| Body Mass Index* (kg/meter2), median (IQR) | 28.9 (25.8, 32.6) | 28.9 (25.8, 32.9) |
| Low Density Lipoprotein mg/dL, median (IQR) | 109 (87, 134) | 110 (87, 133) |
| Low Density Lipoprotein mmol/L, median (IQR) | 2.82 (2.25, 3.47) | 2.85 (2.25, 3.44) |
| Triglycerides mg/dl, median (IQR) | 106 (77, 150) | 106 (76, 147) |
| Triglycerides mmol/L, median (IQR) | 1.20 (0.87, 1.69) | 1.20 (0.86, 1.66) |
| Creatinine mg/dL, median (IQR) | 1.00 (0.86, 1.21) | 1.00 (0.86, 1.21) |
| Creatinine mmol/L, median (IQR) | 0.09 (0.08, 0.11) | 0.09 (0.08, 0.11) |
| Glomerular filtration rate* ml/min, median (IQR) | 70.9 (58.3, 84.3) | 71.4 (58.0, 84.5) |
| No Proteinuria, Albumin to Creatinine ratio < 30 mg/gm (%) | 3277 (79.1) | 3278 (79.0) |
| Smoking status (%) | ||
| Never | 1850 (44.2) | 1853 (44.3) |
| Former | 1797 (42.9) | 1785 (42.6) |
| Current | 541(12.9) | 547 (13.1) |
| Missing | 5 (0.1) | 2 (0.04) |
| Framingham 10-yr cardiovascular disease risk score (%) | ||
| Cardiovascular risk < 10% | 301 (7.2) | 280 (6.7) |
| Cardiovascular risk 10- 20% | 1456 (34.8) | 1486 (35.5) |
| Cardiovascular risk ≥20% | 2431 (58.0) | 2418 (57.8) |
| Medications at Randomization (%) | ||
| Aspirin | 2119 (50.6) | 2193 (52.5) |
| Angiotensin Converting Enzyme Inhibitors | 1506 (35.9) | 1591 (38.0) |
| Angiotensin II Receptor Blockers | 901 (21.5) | 877 (21.0) |
| Beta Blockers | 1254 (29.9) | 1346 (32.2) |
| Calcium Channel Blockers | 1471 (35.1) | 1425 (34.0) |
| Thiazide and potassium sparing diuretics | 1603 (38.3) | 1682 (40.1) |
| Non- Selective alpha Blockers | 189 (4.5) | 200 (4.8) |
| Loop Diuretics | 180 (4.3) | 188 (4.5) |
| Other Antihypertensive medications | 283 (6.8) | 336 (8.0) |
| Statin Lipid Lowering Drugs | 1871 (44.9) | 1793 (43.1) |
| Corticosteroid | 226 (5.4) | 229 (5.5) |
| Hormones | 133 (3.2) | 126 (3.0) |
*
Estimated glomerular filtration rate calculated using MDRD equation (N=17 participants missing baseline value) Body mass index (N=51 participants missing randomization BMI)