Table 2:
Diabetes Incidence rate by Intensive versus Standard blood pressure strategy
| Primary and Secondary outcomes | Standard Blood Pressure N= 4193 |
Intensive Blood Pressure N= 4187 |
|---|---|---|
| Composite diabetes outcome | ||
| N events | 251 | 299 |
| Person time years | 3217.2 | 13225.3 |
| Incidence rate per 1000 person-years of treatment strategy (95% Confidence Intervals) | 19.0 (16.8, 21.5) | 22.6 (20.2, 25.3) |
| Unadjusted Hazard Ratio (95% Confidence Intervals) | Reference | 1.21 (1.02, 1.44) |
| Adjusted Hazard Ratio (95% Confidence Intervals) * | Reference | 1.17 (0.99, 1.39) |
| Fasting glucose ≥ 126mg/ dL (≥6.99 mmol/L) | ||
| N events | 139 | 168 |
| Person time years | 13320.2 | 13235.2 |
| Incidence rate per 1000 person-years of treatment strategy (95% Confidence Intervals) | 10.4 (8.8, 12.3) | 12.7 (10.9, 14.7) |
| Adjusted Hazard Ratio (95% Confidence Intervals) * | Reference | 1.19 (0.95, 1.49) |
| Self-Report of Diabetes | ||
| N events | 117 | 158 |
| Person time years | 13227.2 | 13252.3 |
| Incidence rate per 1000 person-years of treatment strategy (95% Confidence Intervals) | 8.8 (7.4, 10.6) | 11.9 (10.2, 13.9) |
| Adjusted Hazard Ratio (95% Confidence Intervals) * | Reference | 1.34 (1.05, 1.70) |
| New use of hypoglycemic meds | ||
| N events | 94 | 116 |
| Person time years | 13236.2 | 13253.2 |
| Incidence rate per 1000 person-years of treatment strategy (95% Confidence Intervals) | 7.1 (5.8, 8.7) | 8.8 (7.3, 8.5) |
| Adjusted Hazard Ratio (95% Confidence Intervals) * | Reference | 1.22 (0.92, 1.62) |
| Secondary Outcome | N= 2746 | N= 2752 |
| Impaired Fasting glucose: 100- 125 mg/ dL [5.55- 6.94 mmol/L] | ||
| N events | 679 | 793 |
| Person time years | 3013.9 | 2998.7 |
| Incidence rate per 100 person-years of treatment strategy (95% Confidence Intervals) | 22.5 (21.1, 24.1) | 26.4 (24.9, 28.0) |
| Adjusted Hazard Ratio (95% Confidence Intervals) | Reference | 1.17 (1.06, 1.30) |
| Sensitivity Analysis: Randomized Population | N= 4683 | N=4678 |
| N events | 251 | 299 |
| Person time years | 13670 | 13717 |
| Incidence rate per 1000 person-years of treatment strategy (95% Confidence Intervals) | 18.4 (16.2, 20.8) | 21.8 (19.5, 24.4) |
| Adjusted Hazard Ratio (95% Confidence Intervals) † | Reference | 1.18 (0.99, 1.40) |
Confidence intervals for incidence rates calculated using Wilsons distribution
*
Adjusted model includes age, race, gender, body mass index, antihypertensive medication classes at randomization and estimated glomerular filtration rate. Adjusted model includes 8312 participants (N=68 participants missing baseline estimated glomerular filtration rate or body mass index)
†
Adjusted model includes 9246 participants (N=115 participants missing estimated glomerular filtration rate or body mass index)