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Novel PAT methods for quantifying blood flow and oxygenation in deep tissues. (a) Imaging principle of UE-PAF. The ring-shaped ultrasound array tracks the displacement of HIFU-heated blood volume. Adapted with permission from (17). (b) Comparison of sO2 quantification by using the traditional linear unmixing method (left) and eMSOT (right). The yellow arrows indicate a 0% sO2 tube inserted inside the mouse tissue. Scale bar: 1 cm. Adapted with permission from (144).
