Table 3. A multivariate analysis of survival with clinical factors and the miRNA signature.
| univariate Cox | multivariate Cox | |||
|---|---|---|---|---|
| HR(95% CI) | P value | HR(95% CI) | P value | |
| T (T3+T4 vs T1+T2) | 3.56(1.45–8.90) | <0.01* | ||
| N (N1+2 vs N0) | 3.13(2.01–4.86) | <0.01* | ||
| M (M1 vs M0) | 5.23(3.26–8.38) | <0.01* | 2.07(1.1–3.89) | 0.02* |
| stage (stage III+IV vs stage I+II) | 3.76(2.34–6.05) | <0.01* | 5.53(1.5–20.43) | 0.01* |
| age (≥60 vs <60) | 1.02(0.99–1.03) | 0.08 | ||
| venous invasion (yes vs no) | 2.76(1.75–4.37) | <0.01* | ||
| lymphatic invasion (yes vs no) | 2.38(1.51–3.75) | <0.01* | ||
| gender (female vs male) | 1.23(0.81–1.89) | 0.33 | ||
| risk (high vs low) | 2.85(1.81–4.51) | <0.01* | 1.9(1.08–3.36) | 0.03* |
* P<0.05. CI, confidence interval; HR, hazard ratio; miRNA, microRNA.