Table 3. Characteristics of matched patients with severe infections without organ dysfunction stratified according discharge destination after index admission.
| Variable | Home or self-care n = 930 |
Rehabilitation facility n = 930 |
P-value |
|---|---|---|---|
| Age yrs. (range/±SD) | 73.8 (21-98/±11.2) | 73.8 (20-101/±11.2) | 0.955 |
| Male sex (%) | 521 (56.0%) | 521 (56.0%) | 1.000 |
| Charlson Comorbidity Index prior sepsis (±SD) | 3.57 (±2.87) | 3.59 (±2.88) | 0.930 |
| Comorbid condition (%) | |||
| - Chronic obstructive pulmonary disease | 202 (21.7%) | 233 (25.1%) | 0.090 |
| - Ischemic heart disease | 348 (37.4%) | 393 (42.3%) | 0.033 |
| - Diabetes mellitus | 395 (42.5%) | 392 (42.2%) | 0.888 |
| - Malignant neoplasm | 254 (27.3%) | 212 (22.8%) | 0.025 |
| - None of the above | 226 (24.3%) | 234 (25.2%) | 0.667 |
| Degree of nursing care dependency before admission (%) | 1.000 | ||
| - none | 723 (77.7%) | 723 (77.7%) | |
| - 1 | 130 (14.0%) | 130 (14.0%) | |
| - 2 | 65 (7.0%) | 65 (7.0%) | |
| - 3 | 12 (1.3%) | 12 (1.3%) | |
| Etiology of infection (%) | <0.001 | ||
| - Pneumonia | 177 (19.0%) | 246 (26.5%) | |
| - Urinary tract infection | 216 (23.2%) | 165 (17.7%) | |
| - Abdominal infection | 46 (5.0%) | 35 (3.8%) | |
| - Skin or muscle infection | 15 (1.6%) | 27 (2.9%) | |
| - Line infection | 8 (0.9%) | 63 (6.8%) | |
| - Other / Unknown origin | 468 (50.3%) | 394 (42.4%) | |
| Hospital length of stay | <0.001 | ||
| - median [days] (IQR) | 12 (8;19) | 26 (16;42) | |
| - <1 week | 146 (15.7%) | 38 (4.1%) | |
| - 1–4 weeks | 673 (72.4%) | 471 (50.7%) | |
| - 5–10 weeks | 102 (11.0%) | 346 (37.2%) | |
| - >10 weeks | 9 (1.0%) | 75 (8.1%) | |
| Case Mix Index (±SD) | 2.04 (±2.76) | 7.25 (±9.42) | <0.001 |
| Time-dependent risk of 5-year mortality in matched hospital survivors with former severe infection without organ dysfunction | |||
| Crude hazard ratio (HRcrude) | 1.00 (reference) | 0.76 (95%-CI:0.68–0.88) | <0.001 |
| Adjusted hazard ratio (HRadj)* | 1.00 (reference) | 0.81 (95%-CI:0.73–0.90) | <0.001 |
Data are presented as n (%). mean (±SD). median. IQR: interquartile ranges (25th. 75th percentile); degree 1 of nursing care dependency: significant; degree 2 of nursing care dependency: severe; degree 3 of nursing care dependency: heaviest. Only exactly (1:1) matched hospital survivors are included in calculation
* Covariates included in the multivariable-adjusted Cox regression model were for age, sex, Charlson Comorbidity index prior to sepsis, comorbid conditions, degree of nursing care dependency, etiology of infection, hospital length of stay, site of organ dysfunction and Case Mix Index.