Table 6. Multivariate survival analysis of the five biomarker categories of patients with CRC in relation to TNM-stage and primary tumor grade using Cox's proportional hazard regression model.

Variable	n	Hazard ratio (95% CI)	P-value
Primary tumor grade (high vs. low)	23/137	0.46 (0.25–0.84)	0.012
TNM-stage (I/II vs. III/IV)	101/59	4.09 (2.15–7.80)	0.0001
Biomarker category (-1 vs. 0)	27/70	1.93 (0.64–5.83)	0.244
Biomarker category (-1 vs. 1)	27/33	3.17 (1.038–9.67)	0.043
Biomarker category (-1 vs. 2)	27/17	2.50 (0.76–8.21)	0.132
Biomarker category (-1 vs. 3)	27/13	3.56 (1.02–12.43)	0.047

n = number of individuals in the respective category.

CI = confidence interval.