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. 2020 Feb 12;15(2):e0228151. doi: 10.1371/journal.pone.0228151

Table 2. Top ten research questions according to the overall research priority score (RPS).

Rank Research question Group A E D F RPS AEA N
1 What is the impact of interventions for managing at-risk mothers and infants less than 6 months of age in preventing wasting/acute malnutrition in the >6months old? Description 97.5 96.7 93.9 95.9 96.0 93.1 122
2 What is the impact of growth failure during the first 6 months of life on experience of wasting/acute malnutrition after 6 months of age? Description 96.3 88.0 88.9 89.3 90.6 86.4 117
3 How can existing interventions (e.g. growth monitoring, integrated management of childhood illness (IMCI)) better detect and support children (0–59 months) who are failing to thrive/faltering (i.e. those at-risk, not just those already below a z-score threshold)? Development 91.4 90.1 89.8 87.8 89.7 85.6 131
4 What are effective and cost-effective approaches to target the highest risk infants and children 0–59 months (e.g. children with concurrent wasting/acute malnutrition and stunting, children <24 months, etc.) for interventions (food or non-food) to prevent wasting/acute malnutrition? Delivery 93.3 89.4 85.4 88.4 89.1 84.7 129
5 What measures (anthropometric or non-anthropometric) or combinations of measures best identify individual infants and children (0–59 months) by age/sex at most risk of death/other adverse outcomes associated with wasting/acute malnutrition? Description 91.9 89.2 87.4 85.5 88.5 82.8 128
6 What is the role of pre-pregnancy maternal factors (age, health status, nutritional deficits, psychological factors etc.) in determining risk of being born with a low birth weight, low weight-for-length, low mid-upper-arm circumference, premature or small for gestational age? Description 96.7 87.6 86.4 83.2 88.5 83.2 122
7 What measures (anthropometric or non-anthropometric), or combinations of measures, best identify individual infants and children (6–59 months) by age/sex at most risk of wasting/acute malnutrition? Description 92.3 88.2 89.0 81.3 87.7 82.0 128
8 What are effective and cost-effective approaches to integrating wasting/acute malnutrition prevention efforts into health systems (i.e. human resource capacity, financing, supplies and supply chain, etc)? Delivery 86.0 89.9 84.3 89.5 87.4 81.0 128
9 What impact can effective wasting/acute malnutrition prevention interventions/approaches have on levels of stunting (and concurrent wasting and stunting) and vice versa? Description 89.5 85.5 85.0 87.2 86.8 79.5 125
10 How does being born prematurely and/or with foetal growth restriction impact on wasting/acute malnutrition at birth and throughout the first 5 years of life, by sex? Description 93.0 81.6 83.8 86.5 86.2 80.2 122

A = answerability; E = efficacy; D = deliverability; F = fills a gap; RPS = overall research priority score; AEA = average expert agreement; N = number of respondents