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. 2020 Jan 31;16(1):e1007643. doi: 10.1371/journal.pcbi.1007643

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© 2020 Han, Zhang

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 2 — (A) The coarse-grained model considers ribosome allocation between heterologous (i = 1) and endogenous (i = 2) mRNAs. The input, the output, and the resource are total mRNA M_i^T, protein P_i, and total ribosome Rib^T, respectively. Rib^T can either be free ribosome Rib^F or mRNA-bound ribosome. (B) Ribosome competition in a single cell. Top, decrement of the free ribosome fraction (Rib^F/Rib^T) caused by increasing M₁^T. Bottom, negative correlation between endogenous protein (P₂) and heterologous proteins (P₁). Calculations of Rib^F, P₁, and P₂ are described in Note 1.2 in S1 Text, with parameters listed in Table A in S1 Text. (C-F) Correlation between P₁ and P₂ of single cells, r(P₁, P₂). Calculation of r(P₁, P₂) is described in Note 1.3 in S1 Text. M₂^T variability is set as zero for simplicity. (C) Mean Rib^T (10,000) and Rib^T variability (0.1) are set as constants. (D) Mean M₁^T (300) and M₁^T variability (0.1) are set as constants. (E) Mean M₁^T (300) and mean Rib^T (10,000) are set as constants. (F) M₁^T variability and Rib^T variability (both 0.1) are set as constants.