Table 1.
Viral EV cargo secreted by cell type
| Viral Product | Cell Lines | Functions | References |
|---|---|---|---|
| LMP1 | BL, GC, LCL, NPC | Enhance cancer growth, metastasis, invasion, and malignancy, immune regulation | Shair (24), Sheu (27), Meckes (15), Aga (29), Dawson (25), Wheelock (31), Wakisaka (33), Tsai (34) |
| LMP2 | BL, LCL, NPC | Promote EMT, enhance cancer progression, immune modulation | Moody (41), Scholle (42), Fukuda (43), Morrison (44), Cen (45) |
| EBER | BL, LCL, NPC | Alter recipient cell function | Ahmed (47), Zeng (48), Lee (49) |
| BHRF1 | BL, HL, LCL, PTLD | Immune regulation | Cai (58), Skinner (59), and Pegtel (16) |
| BART | BL, HL, NPC, GC, NKTL, LCL, DLBCL, PTLD | Immune regulation Cancer progression | Pegtel (16) Meckes (15), Cai (58), Ramayanti (60), Kang (61), Ambrosio (63), Hooykaas (64), Wong (65) |
| mRNA | LCL and NPC | Enhance infection or cancer progression | Canitano (69) |
BL- Burkitt’s lymphoma
HL- Hodgkin’s lymphoma
LCL- Lymphoblastoid Cell Line
PTLD- Post-transplant lymphoproliferative disease
NPC- Nasopharyngeal Carcinoma
GC- Gastric Carcinoma
NKTL- Natural Killer/T-Cell Lymphoma
DLBCL- Diffuse Large B-Cell Lymphoma