Table 1.
Composition and Excipient Content of Botulinum Neurotoxin Type A Products
| Product Name | Xeomin | Nabota/Jeuveau/Nuceiva | Meditoxin/Neuronox | Botulax/Regenox/Zentox | Relatox | CBTX-A/Prosigne/Lantox |
|---|---|---|---|---|---|---|
| Manufacturer | Merz (Germany) | Daewoong Pharmaceuticals (South Korea) | Medytox Inc (South Korea) | Hugel Inc (South Korea) | Microgen (Russia) | Lanzhou Institute of Biological Products (China) |
| Composition | Purified toxin (150 kDa) | Complex (900 kDa) | Complex | Complex | Complex (900 kDa) | Complex (900 kDa) |
| Excipients | 4.7 mg sucrose 1 mg HSA |
0.5 mg HSA 0.9 mg NaCl |
0.5 mg HSA 0.9 mg NaCl |
0.5 mg HSA 0.9 mg NaCl |
6 mg gelatin 12 mg maltose |
Gelatin, dextran, sucrose |
| Clostridial protein per 100 U (pg) | 416 pg | N/A | N/A | 5,000 pg8 | N/A | N/A |
N/A, information not publicly available; NaCl, sodium chloride.
Modified from Frevert et al.18