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. 2020 Jan 24;8(1):e2627. doi: 10.1097/GOX.0000000000002627

Table 2.

Known Esthetic (Facial Indications) Trials for Commercially Available Esthetic Toxins

ClinicalTrials.gov-listed Completed Phase III/IV Clinical Trials Using Commercial Botulinum Toxin A for Medical Esthetic Interventions with Disclosed Results, in Adult Patients (over 18 y)
Toxin Name/Generic Name NCT Number Title Conditions
Nabota/prabotulinumtoxinA Results not posted on ClinicalTrials.gov
Botulax/letibotulinum toxin A
Neuronox
Coretox
Xeomin/incobotulinumtoxinA NCT00770211 IncobotulinumtoxinA (Xeomin) Versus Placebo in the Treatment of Glabellar Frown Lines Moderate to severe glabellar frown lines
NCT00770029 IncobotulinumtoxinA (Xeomin) Versus Placebo in the Treatment of Glabellar Frown Lines No. 2 Moderate to severe glabellar frown lines
NCT00406367 IncobotulinumtoxinA (Xeomin) Versus Placebo in the Treatment of Blepharospasm Blepharospasm
NCT00986570 Clinical Trial to Assess Efficacy, Safety and Tolerability of Botulinum Toxin A (Xeomin) in Treatment of Expression Wrinkles in the Upper Third of the Face Skin aging
NCT00777803 NT 201 (Xeomin /Bocouture) in Comparison With Clostridium botulinum Toxin Type A in the Treatment of Glabellar Frown Lines Glabellar frown lines
NCT01728337 Phase Iv Study On Muscle Activity Of Two Commercial Preparations Of Botulinum Sun-induced wrinkles
NCT01896895 Efficacy and Safety Study of Botulinum Toxin Type A Against Placebo to Treat Abnormal Contraction or Twitch of the Eyelid BEB
NCT01814774 A Retrospective Chart Review of BOTOX and Xeomin for the Treatment of Cervical Dystonia and Blepharospasm Cervical dystonia/blepharospasm
NCT02096081 The Treatment of Glabellar Frown Lines Glabellar frown lines
NCT00959907 Comparison of Two Commercial Preparations of Botulinum Toxin Type A Wrinkles in frontal area
NCT01271452 Safety and Efficacy of Two Types of Botulinum Toxin Type A For the Treatment of Glabellar Lines Glabellar lines
NCT01608659 An Observational Retrospective Study to Evaluate Treatment Patterns of Botulinum Toxin Type A Facial rhytides
NCT03048383 Comparison of Three Botulinum Neuromodulators for Management of Facial Synkinesis Facial nerve injuries/facial paresis associated with facial nerve dysfunction/facial asymmetry/synkinesis
NCT00761592 Comparison of Two Botulinum Type A Products in the Treatment of Blepharospasm Blepharospasm
NCT01014871 Comparison of Two Botulinum Toxins Type A on Forehead Wrinkles Wrinkles
Botox/ OnabotulinumtoxinA NCT02353871 Efficacy and Safety of Clostridium botulinum Toxin Type A to Improve Appearance of Moderate to Severe Glabellar Lines Moderate to severe glabellar lines
NCT01391312 Patient Satisfaction Study of BOTOX Cosmetic in the Treatment of Moderate to Severe Frown Lines Glabellar frown lines
NCT01269801 Study of BOTOX and JUVEDERM for Treatment of Moderate to Severe Facial Wrinkles and Folds Wrinkles
NCT02261467 A Safety and Efficacy Study of OnabotulinumtoxinA in Forehead and Glabellar Facial Rhytides Forehead rhytides/glabellar rhytides
NCT02261493 A Safety and Efficacy Study of OnabotulinumtoxinA in Upper Facial Rhytides Facial rhytides/glabellar rhytides
NCT02195687 BOTOX in the Treatment of Crow’s Feet Lines in China Lateral canthal lines/Crow’s feet lines
NCT02450526 Dysport in the Treatment of Glabellar Lines in Chinese Subjects Glabellar lines
NCT01777620 A Study of Subject Satisfaction With BOTOX Cosmetic Treatment in Facial Rhytides Facial rhytides
NCT02493946 Efficacy and Safety of Botulinum Toxin Type A Haemagglutinin Complex Next Generation (BTX-A-HAC NG) in Glabellar Lines Glabellar lines
NCT01586819 Lateral Canthal Rhytides With Medium Depth Chemical Peel With or Without Pretreatment With Botulinum Toxin A Wrinkles
NCT01189747 Safety and Efficacy Study of Botulinum Toxin Type A for the Treatment of Crow’s Feet Lines Lateral canthus rhytides/Crow’s feet lines
NCT01797094 BOTOX in the Treatment of Upper Facial Lines in Japan Upper facial rhytides/Crow’s feet lines/glabellar lines/frown lines
NCT01814670 Treatment With Botulinum Toxin Type A (BOTOX) in Chinese Patients With Moderate to Severe Frown Lines Glabellar rhytides
NCT00959907 Comparison of Two Commercial Preparations of Botulinum Toxin Type A Wrinkles in frontal area
NCT01189760 Safety and Efficacy Study of Botulinum Toxin Type A for the Treatment of Crow’s Feet Lines and Frown Lines Facial rhytides/Crow’s feet lines/glabellar lines
NCT01224015 Safety and Efficacy Study of Botulinum Toxin Type A for the Treatment of Crow’s Feet Lines and Frown Lines Facial rhytides/Crow’s feet lines/glabellar lines
NCT01271452 Safety and Efficacy of Two Types of Botulinum Toxin Type A For the Treatment of Glabellar Lines Glabellar lines
NCT00989768 Field of Effects of Two Commercial Preparations of Botulinum Toxin Type A Wrinkles in frontal area
NCT01797081 BOTOX in the Treatment of Crow’s Feet Lines in Japan Lateral canthus rhytides/Crow’s feet lines
NCT00777803 NT 201 (Xeomin /Bocouture) in Comparison With Clostridium botulinum Toxin Type A in the Treatment of Glabellar Frown Lines Glabellar frown lines
NCT01728337 Phase Iv Study On Muscle Activity Of Two Commercial Preparations Of Botulinum Sun-induced wrinkles
NCT02176356 Patient Satisfaction Study of Combined Facial Treatment With BOTOX Cosmetic, JUVÉDERM and LATISSE (HARMONY Study) Facial rhytides/Crow’s feet lines/glabellar lines/nasolabial fold
NCT00856414 Patient Satisfaction With Treatment of BOTOX Cosmetic for the Temporary Correction of Moderate to Severe Glabellar Lines Skin aging
NCT00986570 Clinical Trial to Assess Efficacy, Safety and Tolerability of Botulinum Toxin A (Xeomin) in Treatment of Expression Wrinkles in the Upper Third of the Face Skin aging
NCT01529203 Subjects’ Satisfaction on Pan Facial Aesthetic Enhancement After Treatment With Azzalure and the Restylane Range Aging
NCT02718118 Comparison of Dysport Reconstitution at 1.5 mL and 2.5 mL for the Treatment of Moderate to Severe Glabellar Lines Glabellar lines/wrinkles
NCT02096081 The Treatment of Glabellar Frown Lines Glabellar frown lines
NCT00761592 Comparison of Two Botulinum Type A Products in the Treatment of Blepharospasm Blepharospasm
NCT01896895 Efficacy and Safety Study of Botulinum Toxin Type A Against Placebo to Treat Abnormal Contraction or Twitch of the Eyelid BEB
NCT00770211 IncobotulinumtoxinA (Xeomin) Versus Placebo in the Treatment of Glabellar Frown Lines Moderate to severe glabellar frown lines
NCT00770029 IncobotulinumtoxinA (Xeomin) Versus Placebo in the Treatment of Glabellar Frown Lines No. 2 Moderate to severe glabellar frown lines
NCT00406367 IncobotulinumtoxinA (Xeomin) Versus Placebo in the Treatment of Blepharospasm Blepharospasm
NCT02334436 A Phase III Study to Demonstrate the Safety and Efficacy of DWP-450 to Treat Glabellar Lines - EV-002 Glabellar Frown lines
NCT02334423 A Phase III Study to Demonstrate the Safety and Efficacy of DWP-450 to Treat Glabellar Lines - EV001 Glabellar frown lines
Dysport/ AbobotulinumtoxinA NCT01529203 Subjects’ Satisfaction on Pan Facial Aesthetic Enhancement After Treatment With Azzalure and the Restylane Range Aging
NCT01896895 Efficacy and Safety Study of Botulinum Toxin Type A Against Placebo to Treat Abnormal Contraction or Twitch of the Eyelid BEB
NCT00761592 Comparison of Two Botulinum Type A Products in the Treatment of Blepharospasm Blepharospasm
NCT00406367 IncobotulinumtoxinA (Xeomin) Versus Placebo in the Treatment of Blepharospasm Blepharospasm
NCT01777620 A Study of Subject Satisfaction With BOTOX Cosmetic Treatment in Facial Rhytides Facial rhytides
NCT01189760 Safety and Efficacy Study of Botulinum Toxin Type A for the Treatment of Crow’s Feet Lines and Frown Lines Facial rhytides/Crow’s feet lines/glabellar lines
NCT01224015 Safety and Efficacy Study of Botulinum Toxin Type A for the Treatment of Crow’s Feet Lines and Frown Lines Facial rhytides/Crow’s feet lines/glabellar lines
NCT02176356 Patient Satisfaction Study of Combined Facial Treatment With BOTOX Cosmetic, JUVEDERM and LATISSE (HARMONY Study) Facial rhytides/Crow’s feet lines/glabellar lines/nasolabial fold
NCT02261493 A Safety and Efficacy Study of OnabotulinumtoxinA in Upper Facial Rhytides Facial rhytides/glabellar rhytides
NCT02261467 A Safety and Efficacy Study of OnabotulinumtoxinA in Forehead and Glabellar Facial Rhytides Forehead rhytides/glabellar rhytides
NCT01391312 Patient Satisfaction Study of BOTOX Cosmetic in the Treatment of Moderate to Severe Frown Lines Glabellar frown lines
NCT00777803 NT 201 (Xeomin /Bocouture) in Comparison With Clostridium botulinum Toxin Type A in the Treatment of Glabellar Frown Lines Glabellar frown lines
NCT02096081 The Treatment of Glabellar Frown Lines Glabellar frown lines
NCT02334436 A Phase III Study to Demonstrate the Safety and Efficacy of DWP-450 to Treat Glabellar Lines - EV-002 Glabellar frown lines
NCT02334423 A Phase III Study to Demonstrate the Safety and Efficacy of DWP-450 to Treat Glabellar Lines - EV001 Glabellar frown lines
NCT02450526 Dysport in the Treatment of Glabellar Lines in Chinese Subjects Glabellar lines
NCT02493946 Efficacy and Safety of Botulinum Toxin Type A Haemagglutinin Complex Next Generation (BTX-A-HAC NG) in Glabellar Lines Glabellar lines
NCT01271452 Safety and Efficacy of Two Types of Botulinum Toxin Type A For the Treatment of Glabellar Lines Glabellar lines
NCT02718118 Comparison of Dysport Reconstitution at 1.5 mL and 2.5 mL for the Treatment of Moderate to Severe Glabellar Lines Glabellar lines/wrinkles
NCT01814670 Treatment With Botulinum Toxin Type A (BOTOX) in Chinese Patients With Moderate to Severe Frown Lines Glabellar rhytides
NCT02195687 BOTOX in the Treatment of Crow’s Feet Lines in China Lateral canthal lines/Crow’s feet lines
NCT01189747 Safety and Efficacy Study of Botulinum Toxin Type A for the Treatment of Crow’s Feet Lines Lateral canthus rhytides/Crow’s feet lines
NCT01797081 BOTOX in the Treatment of Crow’s Feet Lines in Japan Lateral canthus rhytides/Crow’s feet lines
NCT00770211 IncobotulinumtoxinA (Xeomin) Versus Placebo in the Treatment of Glabellar Frown Lines Moderate to severe glabellar frown lines
NCT00770029 IncobotulinumtoxinA (Xeomin) Versus Placebo in the Treatment of Glabellar Frown Lines No. 2 Moderate to severe glabellar frown lines
NCT02353871 Efficacy and Safety of Clostridium botulinum Toxin Type A to Improve Appearance of Moderate to Severe Glabellar Lines Moderate to severe glabellar lines
NCT00986570 Clinical Trial to Assess Efficacy, Safety and Tolerability of Botulinum Toxin A (Xeomin) in Treatment of Expression Wrinkles in the Upper Third of the Face Skin aging
NCT00856414 Patient Satisfaction With Treatment of BOTOX Cosmetic for the Temporary Correction of Moderate to Severe Glabellar Lines Skin aging
NCT01728337 Phase Iv Study On Muscle Activity Of Two Commercial Preparations Of Botulinum Sun-induced wrinkles
NCT01797094 BOTOX in the Treatment of Upper Facial Lines in Japan Upper facial rhytides/Crow’s feet lines/glabellar lines/frown lines
NCT01269801 Study of BOTOX and JUVEDERM for Treatment of Moderate to Severe Facial Wrinkles and Folds Wrinkles
NCT01586819 Lateral Canthal Rhytides With Medium Depth Chemical Peel With or Without Pretreatment With Botulinum Toxin A Wrinkles
NCT00959907 Comparison of Two Commercial Preparations of Botulinum Toxin Type A Wrinkles in frontal area
NCT00989768 Field of Effects of Two Commercial Preparations of Botulinum Toxin Type A Wrinkles in frontal area

Trials on nonesthetic indications on nonfacial areas, such as upper limb spasticity, are not relevant to our discussion and are excluded.

BEB, bilateral blepharospasm; NCT, national clinical trial.