Table 2.
ClinicalTrials.gov-listed Completed Phase III/IV Clinical Trials Using Commercial Botulinum Toxin A for Medical Esthetic Interventions with Disclosed Results, in Adult Patients (over 18 y) | ||||
Toxin Name/Generic Name | NCT Number | Title | Conditions | |
Nabota/prabotulinumtoxinA | Results not posted on ClinicalTrials.gov | |||
Botulax/letibotulinum toxin A | ||||
Neuronox | ||||
Coretox | ||||
Xeomin/incobotulinumtoxinA | NCT00770211 | IncobotulinumtoxinA (Xeomin) Versus Placebo in the Treatment of Glabellar Frown Lines | Moderate to severe glabellar frown lines | |
NCT00770029 | IncobotulinumtoxinA (Xeomin) Versus Placebo in the Treatment of Glabellar Frown Lines No. 2 | Moderate to severe glabellar frown lines | ||
NCT00406367 | IncobotulinumtoxinA (Xeomin) Versus Placebo in the Treatment of Blepharospasm | Blepharospasm | ||
NCT00986570 | Clinical Trial to Assess Efficacy, Safety and Tolerability of Botulinum Toxin A (Xeomin) in Treatment of Expression Wrinkles in the Upper Third of the Face | Skin aging | ||
NCT00777803 | NT 201 (Xeomin /Bocouture) in Comparison With Clostridium botulinum Toxin Type A in the Treatment of Glabellar Frown Lines | Glabellar frown lines | ||
NCT01728337 | Phase Iv Study On Muscle Activity Of Two Commercial Preparations Of Botulinum | Sun-induced wrinkles | ||
NCT01896895 | Efficacy and Safety Study of Botulinum Toxin Type A Against Placebo to Treat Abnormal Contraction or Twitch of the Eyelid | BEB | ||
NCT01814774 | A Retrospective Chart Review of BOTOX and Xeomin for the Treatment of Cervical Dystonia and Blepharospasm | Cervical dystonia/blepharospasm | ||
NCT02096081 | The Treatment of Glabellar Frown Lines | Glabellar frown lines | ||
NCT00959907 | Comparison of Two Commercial Preparations of Botulinum Toxin Type A | Wrinkles in frontal area | ||
NCT01271452 | Safety and Efficacy of Two Types of Botulinum Toxin Type A For the Treatment of Glabellar Lines | Glabellar lines | ||
NCT01608659 | An Observational Retrospective Study to Evaluate Treatment Patterns of Botulinum Toxin Type A | Facial rhytides | ||
NCT03048383 | Comparison of Three Botulinum Neuromodulators for Management of Facial Synkinesis | Facial nerve injuries/facial paresis associated with facial nerve dysfunction/facial asymmetry/synkinesis | ||
NCT00761592 | Comparison of Two Botulinum Type A Products in the Treatment of Blepharospasm | Blepharospasm | ||
NCT01014871 | Comparison of Two Botulinum Toxins Type A on Forehead Wrinkles | Wrinkles | ||
Botox/ OnabotulinumtoxinA | NCT02353871 | Efficacy and Safety of Clostridium botulinum Toxin Type A to Improve Appearance of Moderate to Severe Glabellar Lines | Moderate to severe glabellar lines | |
NCT01391312 | Patient Satisfaction Study of BOTOX Cosmetic in the Treatment of Moderate to Severe Frown Lines | Glabellar frown lines | ||
NCT01269801 | Study of BOTOX and JUVEDERM for Treatment of Moderate to Severe Facial Wrinkles and Folds | Wrinkles | ||
NCT02261467 | A Safety and Efficacy Study of OnabotulinumtoxinA in Forehead and Glabellar Facial Rhytides | Forehead rhytides/glabellar rhytides | ||
NCT02261493 | A Safety and Efficacy Study of OnabotulinumtoxinA in Upper Facial Rhytides | Facial rhytides/glabellar rhytides | ||
NCT02195687 | BOTOX in the Treatment of Crow’s Feet Lines in China | Lateral canthal lines/Crow’s feet lines | ||
NCT02450526 | Dysport in the Treatment of Glabellar Lines in Chinese Subjects | Glabellar lines | ||
NCT01777620 | A Study of Subject Satisfaction With BOTOX Cosmetic Treatment in Facial Rhytides | Facial rhytides | ||
NCT02493946 | Efficacy and Safety of Botulinum Toxin Type A Haemagglutinin Complex Next Generation (BTX-A-HAC NG) in Glabellar Lines | Glabellar lines | ||
NCT01586819 | Lateral Canthal Rhytides With Medium Depth Chemical Peel With or Without Pretreatment With Botulinum Toxin A | Wrinkles | ||
NCT01189747 | Safety and Efficacy Study of Botulinum Toxin Type A for the Treatment of Crow’s Feet Lines | Lateral canthus rhytides/Crow’s feet lines | ||
NCT01797094 | BOTOX in the Treatment of Upper Facial Lines in Japan | Upper facial rhytides/Crow’s feet lines/glabellar lines/frown lines | ||
NCT01814670 | Treatment With Botulinum Toxin Type A (BOTOX) in Chinese Patients With Moderate to Severe Frown Lines | Glabellar rhytides | ||
NCT00959907 | Comparison of Two Commercial Preparations of Botulinum Toxin Type A | Wrinkles in frontal area | ||
NCT01189760 | Safety and Efficacy Study of Botulinum Toxin Type A for the Treatment of Crow’s Feet Lines and Frown Lines | Facial rhytides/Crow’s feet lines/glabellar lines | ||
NCT01224015 | Safety and Efficacy Study of Botulinum Toxin Type A for the Treatment of Crow’s Feet Lines and Frown Lines | Facial rhytides/Crow’s feet lines/glabellar lines | ||
NCT01271452 | Safety and Efficacy of Two Types of Botulinum Toxin Type A For the Treatment of Glabellar Lines | Glabellar lines | ||
NCT00989768 | Field of Effects of Two Commercial Preparations of Botulinum Toxin Type A | Wrinkles in frontal area | ||
NCT01797081 | BOTOX in the Treatment of Crow’s Feet Lines in Japan | Lateral canthus rhytides/Crow’s feet lines | ||
NCT00777803 | NT 201 (Xeomin /Bocouture) in Comparison With Clostridium botulinum Toxin Type A in the Treatment of Glabellar Frown Lines | Glabellar frown lines | ||
NCT01728337 | Phase Iv Study On Muscle Activity Of Two Commercial Preparations Of Botulinum | Sun-induced wrinkles | ||
NCT02176356 | Patient Satisfaction Study of Combined Facial Treatment With BOTOX Cosmetic, JUVÉDERM and LATISSE (HARMONY Study) | Facial rhytides/Crow’s feet lines/glabellar lines/nasolabial fold | ||
NCT00856414 | Patient Satisfaction With Treatment of BOTOX Cosmetic for the Temporary Correction of Moderate to Severe Glabellar Lines | Skin aging | ||
NCT00986570 | Clinical Trial to Assess Efficacy, Safety and Tolerability of Botulinum Toxin A (Xeomin) in Treatment of Expression Wrinkles in the Upper Third of the Face | Skin aging | ||
NCT01529203 | Subjects’ Satisfaction on Pan Facial Aesthetic Enhancement After Treatment With Azzalure and the Restylane Range | Aging | ||
NCT02718118 | Comparison of Dysport Reconstitution at 1.5 mL and 2.5 mL for the Treatment of Moderate to Severe Glabellar Lines | Glabellar lines/wrinkles | ||
NCT02096081 | The Treatment of Glabellar Frown Lines | Glabellar frown lines | ||
NCT00761592 | Comparison of Two Botulinum Type A Products in the Treatment of Blepharospasm | Blepharospasm | ||
NCT01896895 | Efficacy and Safety Study of Botulinum Toxin Type A Against Placebo to Treat Abnormal Contraction or Twitch of the Eyelid | BEB | ||
NCT00770211 | IncobotulinumtoxinA (Xeomin) Versus Placebo in the Treatment of Glabellar Frown Lines | Moderate to severe glabellar frown lines | ||
NCT00770029 | IncobotulinumtoxinA (Xeomin) Versus Placebo in the Treatment of Glabellar Frown Lines No. 2 | Moderate to severe glabellar frown lines | ||
NCT00406367 | IncobotulinumtoxinA (Xeomin) Versus Placebo in the Treatment of Blepharospasm | Blepharospasm | ||
NCT02334436 | A Phase III Study to Demonstrate the Safety and Efficacy of DWP-450 to Treat Glabellar Lines - EV-002 | Glabellar Frown lines | ||
NCT02334423 | A Phase III Study to Demonstrate the Safety and Efficacy of DWP-450 to Treat Glabellar Lines - EV001 | Glabellar frown lines | ||
Dysport/ AbobotulinumtoxinA | NCT01529203 | Subjects’ Satisfaction on Pan Facial Aesthetic Enhancement After Treatment With Azzalure and the Restylane Range | Aging | |
NCT01896895 | Efficacy and Safety Study of Botulinum Toxin Type A Against Placebo to Treat Abnormal Contraction or Twitch of the Eyelid | BEB | ||
NCT00761592 | Comparison of Two Botulinum Type A Products in the Treatment of Blepharospasm | Blepharospasm | ||
NCT00406367 | IncobotulinumtoxinA (Xeomin) Versus Placebo in the Treatment of Blepharospasm | Blepharospasm | ||
NCT01777620 | A Study of Subject Satisfaction With BOTOX Cosmetic Treatment in Facial Rhytides | Facial rhytides | ||
NCT01189760 | Safety and Efficacy Study of Botulinum Toxin Type A for the Treatment of Crow’s Feet Lines and Frown Lines | Facial rhytides/Crow’s feet lines/glabellar lines | ||
NCT01224015 | Safety and Efficacy Study of Botulinum Toxin Type A for the Treatment of Crow’s Feet Lines and Frown Lines | Facial rhytides/Crow’s feet lines/glabellar lines | ||
NCT02176356 | Patient Satisfaction Study of Combined Facial Treatment With BOTOX Cosmetic, JUVEDERM and LATISSE (HARMONY Study) | Facial rhytides/Crow’s feet lines/glabellar lines/nasolabial fold | ||
NCT02261493 | A Safety and Efficacy Study of OnabotulinumtoxinA in Upper Facial Rhytides | Facial rhytides/glabellar rhytides | ||
NCT02261467 | A Safety and Efficacy Study of OnabotulinumtoxinA in Forehead and Glabellar Facial Rhytides | Forehead rhytides/glabellar rhytides | ||
NCT01391312 | Patient Satisfaction Study of BOTOX Cosmetic in the Treatment of Moderate to Severe Frown Lines | Glabellar frown lines | ||
NCT00777803 | NT 201 (Xeomin /Bocouture) in Comparison With Clostridium botulinum Toxin Type A in the Treatment of Glabellar Frown Lines | Glabellar frown lines | ||
NCT02096081 | The Treatment of Glabellar Frown Lines | Glabellar frown lines | ||
NCT02334436 | A Phase III Study to Demonstrate the Safety and Efficacy of DWP-450 to Treat Glabellar Lines - EV-002 | Glabellar frown lines | ||
NCT02334423 | A Phase III Study to Demonstrate the Safety and Efficacy of DWP-450 to Treat Glabellar Lines - EV001 | Glabellar frown lines | ||
NCT02450526 | Dysport in the Treatment of Glabellar Lines in Chinese Subjects | Glabellar lines | ||
NCT02493946 | Efficacy and Safety of Botulinum Toxin Type A Haemagglutinin Complex Next Generation (BTX-A-HAC NG) in Glabellar Lines | Glabellar lines | ||
NCT01271452 | Safety and Efficacy of Two Types of Botulinum Toxin Type A For the Treatment of Glabellar Lines | Glabellar lines | ||
NCT02718118 | Comparison of Dysport Reconstitution at 1.5 mL and 2.5 mL for the Treatment of Moderate to Severe Glabellar Lines | Glabellar lines/wrinkles | ||
NCT01814670 | Treatment With Botulinum Toxin Type A (BOTOX) in Chinese Patients With Moderate to Severe Frown Lines | Glabellar rhytides | ||
NCT02195687 | BOTOX in the Treatment of Crow’s Feet Lines in China | Lateral canthal lines/Crow’s feet lines | ||
NCT01189747 | Safety and Efficacy Study of Botulinum Toxin Type A for the Treatment of Crow’s Feet Lines | Lateral canthus rhytides/Crow’s feet lines | ||
NCT01797081 | BOTOX in the Treatment of Crow’s Feet Lines in Japan | Lateral canthus rhytides/Crow’s feet lines | ||
NCT00770211 | IncobotulinumtoxinA (Xeomin) Versus Placebo in the Treatment of Glabellar Frown Lines | Moderate to severe glabellar frown lines | ||
NCT00770029 | IncobotulinumtoxinA (Xeomin) Versus Placebo in the Treatment of Glabellar Frown Lines No. 2 | Moderate to severe glabellar frown lines | ||
NCT02353871 | Efficacy and Safety of Clostridium botulinum Toxin Type A to Improve Appearance of Moderate to Severe Glabellar Lines | Moderate to severe glabellar lines | ||
NCT00986570 | Clinical Trial to Assess Efficacy, Safety and Tolerability of Botulinum Toxin A (Xeomin) in Treatment of Expression Wrinkles in the Upper Third of the Face | Skin aging | ||
NCT00856414 | Patient Satisfaction With Treatment of BOTOX Cosmetic for the Temporary Correction of Moderate to Severe Glabellar Lines | Skin aging | ||
NCT01728337 | Phase Iv Study On Muscle Activity Of Two Commercial Preparations Of Botulinum | Sun-induced wrinkles | ||
NCT01797094 | BOTOX in the Treatment of Upper Facial Lines in Japan | Upper facial rhytides/Crow’s feet lines/glabellar lines/frown lines | ||
NCT01269801 | Study of BOTOX and JUVEDERM for Treatment of Moderate to Severe Facial Wrinkles and Folds | Wrinkles | ||
NCT01586819 | Lateral Canthal Rhytides With Medium Depth Chemical Peel With or Without Pretreatment With Botulinum Toxin A | Wrinkles | ||
NCT00959907 | Comparison of Two Commercial Preparations of Botulinum Toxin Type A | Wrinkles in frontal area | ||
NCT00989768 | Field of Effects of Two Commercial Preparations of Botulinum Toxin Type A | Wrinkles in frontal area |
Trials on nonesthetic indications on nonfacial areas, such as upper limb spasticity, are not relevant to our discussion and are excluded.
BEB, bilateral blepharospasm; NCT, national clinical trial.