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. 2020 Jan 15;128(1):017002. doi: 10.1289/EHP5221

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EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted.

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Figures 2A and 2B are bar graphs plotting relative fold change in TFF1 expression (ranging from 0 to 20) and gamma H 2 A X intensity per nucleus (ranging from 0 to 250) (y-axis) across control, E subscript 2 (10 nanomolar), BP-3 (5 micromolar), PP (5 micromolar) for negative and positive fulvestrant (x-axis). — TFF1 expression and $γ - H 2 AX$ intensity in T47D cells treated with $17 β -estradiol$ ( $E_{2}$ ), benzophenone-3 (BP-3), or propylparaben (PP) for $24 h$ with or without the ER antagonist fulvestrant. (A) Inhibition of TFF1 expression following treatment of $10 nM$ $E_{2}$ , $5 μ M$ BP-3, and $5 μ M$ PP when cotreated with fulvestrant (ICI 182 780, $1 μ M$ ) compared with $10 nM$ $E_{2}$ , $5 μ M$ BP-3, and $5 μ M$ PP treatments without fulvestrant. (B) Quantification of nuclear $γ - H 2 AX$ following cotreatment of fulvestrant ( $1 μ M$ ) with $E_{2}$ ( $10 nM$ ), BP-3 ( $5 μ M$ ), or PP ( $5 μ M$ ) compared with $E_{2}$ ( $10 nM$ ), BP-3 ( $5 μ M$ ), or PP ( $5 μ M$ ) without fulvestrant treatment, respectively. *** $p < 0.0001$ compared control to xenoestrogens treatment and ^### $p < 0.001$ compared with negative fulvestrant and with positive fulvestrant using multiple comparison for 2-way ANOVA. $n = 3$ biological replicates. All graphs show mean ± SEM.