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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: J Invest Dermatol. 2018 Nov 16;139(5):1118–1126. doi: 10.1016/j.jid.2018.10.038

Figure 5. Inhibition of collagen prolyl 4-hydroxylase has antiproliferative effects on melanoma cells via induction of apoptosis.

Figure 5.

(a, b) Inhibition of proliferation of PMWK (blue) and SKMEL23 (green) by EDHB. Data are mean ± standard error of the mean over biological repeats (n = 3) performed in six replicates. Significance: two-way analysis of variance with Tukey’s post-hoc testing. (c) Antiproliferative effect of EDBH and PythiDC on PMWK and SKMEL23. Data are mean ± standard error of the mean (n = 2) in triplicate. Significance: one-way analysis of variance with Sidak’s post-hoc testing. (d) EDHB induces apoptosis in PMWK cells. Apoptosis was measured via Annexin V staining on day 3. Data are mean ± standard error of the mean (n = 3). Live cell population not shown. Significance: two-way analysis of variance with Tukey’s post-hoc testing. *Differences in early-stage apoptosis. •Differences in late-stage apoptosis. EDHB, ethyl dihydroxybennzoic acid; PythiDC, 2-(5-carboxythiazol-2-yl)pyridine-5-carboxylic acid.