Table 3. Mutation rates in wild-type and MMR-deficient strains from bacterial species as obtained from MA datasets.
|
Type of mutation |
Mutation rates per nucleotide per generation (x10−10)* | ||||||||||||||||||||||||
| This study | Previous studies† | ||||||||||||||||||||||||
|
Mycobacterium smegmatis |
Corynebacterium glutamicum |
Escherichia coli |
Deinococcus radiodurans‡ |
Bacillus subtilis |
Pseudomonas fluorescens |
Vibrio cholerae | Vibrio fischeri | ||||||||||||||||||
| wt | ΔnucS | Increase§ | wt | ΔnucS | Increase | wt | ΔmutL | Increase | wt | ΔmutL | Increase | wt | ΔmutS | Increase | wt | ΔmutS | Increase | wt | ΔmutS | Increase | wt | ΔmutS | Increase | ||
| Total BPSs | 5.8 | 236.8 | 40.9 | 8.9 | 461.3 | 51.7 | 2 | 274.7 | 137 | 5 | 18.6 | 3.7 | 3.3 | 331 | 101.1 | 0.9 | 286.9 | 308.2 | 1.1 | 90.6 | 84.9 | 2 | 654.7 | 322 | |
| Transitions | 3.6 | 233.1 | 64.7 | 6.2 | 457.8 | 73.4 | 1.1 | 268.4 | 238.2 | 3.2 | 17.7 | 5.6 | 2.5 | 321.7 | 130.7 | 0.6 | 283.3 | 481.1 | 0.6 | 89.1 | 137.1 | 0.9 | 641.2 | 681.8 | |
| A:T>G:C | 0.9 | 139.5 | 147.1 | 2.3 | 205.4 | 90.6 | 0.4 | 192.9 | 457.5 | 1.1 | 6.1 | 5.4 | 1.2 | 158.3 | 128.2 | 0.2 | 144.4 | 754.7 | 0.1 | 44.5 | 302.8 | 0.3 | 387.4 | 1456.6 | |
| G:C>A:T | 2.7 | 93.6 | 35.3 | 4 | 252.4 | 63.5 | 0.7 | 75.6 | 107.1 | 2 | 11.6 | 5.7 | 1.2 | 163.4 | 133.3 | 0.4 | 138.9 | 349.3 | 0.5 | 44.6 | 88.7 | 0.7 | 253.7 | 376.2 | |
| Transversions | 2.2 | 3.7 | 1.7 | 2.7 | 3.5 | 1.3 | 0.9 | 6.3 | 7.1 | 1.8 | 0.9 | 0.5 | 0.8 | 9.3 | 11.4 | 0.3 | 3.7 | 10.7 | 0.4 | 1.5 | 3.6 | 1.1 | 13.5 | 12.4 | |
| A:T>T:A | 0.2 | 0.7 | 3.6 | 0.3 | 0 | 0 | 0.1 | 2.4 | 16.2 | 0.2 | 0.3 | 1.2 | 0.3 | 3.9 | 14.8 | 0.01 | 0.7 | 59.9 | 0.05 | 0.4 | 7.6 | 0.04 | 5.8 | 153.7 | |
| A:T>C:G | 0.6 | 0.6 | 1 | 1 | 2.6 | 2.6 | 0.3 | 1.7 | 5.2 | 1.1 | 0.3 | 0.3 | 0.3 | 2.7 | 10.6 | 0.1 | 0.4 | 3.7 | 0.1 | 0.3 | 2 | 0.2 | 0.9 | 3.9 | |
| G:C>T:A | 1.1 | 1.8 | 1.5 | 1 | 0.9 | 0.9 | 0.3 | 1.7 | 6.5 | 0.4 | 0 | 0 | 0.2 | 1 | 4.5 | 0.1 | 0.9 | 6.6 | 0.2 | 0.4 | 1.8 | 0.7 | 4.9 | 6.8 | |
| G:C>C:G | 0.3 | 0.7 | 2.4 | 0.4 | 0 | 0 | 0.1 | 0.5 | 3.5 | 0.1 | 0.3 | 2.5 | 0.1 | 1.8 | 23.4 | 0.1 | 1.7 | 18.2 | 0.05 | 0.5 | 11.5 | 0.1 | 1.8 | 19.4 | |
| Total indels | 1.8 | 1.8 | 1 | 0.9 | 0 | 0 | 0.2 | 51.7 | 286.3 | 0.2 | 4.7 | 21.4 | 1.2 | 52.3 | 44.3 | 0.1 | 24.7 | 209.5 | 0.2 | 24.2 | 142.2 | 0.6 | 57.6 | 101.1 | |
| Insertions | 1.2 | 1.4 | 1.1 | 0.4 | 0 | 0 | ǁ | 0.1 | 2.2 | 19 | 0.3 | 31.9 | 111.4 | 0.03 | 22.8 | 687.1 | 0.04 | 12.5 | 323.2 | 0.2 | 25.2 | 120.6 | |||
| Deletions | 0.6 | 0.4 | 0.7 | 0.5 | 0 | 0 | 0.1 | 2.5 | 24.2 | 0.9 | 20.4 | 22.9 | 0.1 | 1.9 | 22.6 | 0.1 | 11.7 | 89 | 0.4 | 32.4 | 89.8 | ||||
| Overall | 7.6 | 238.5 | 31.5 | 9.8 | 461.3 | 46.9 | 2.2 | 326.4 | 149.4 | 5.2 | 23.3 | 4.5 | 4.5 | 383.3 | 86.1 | 1 | 311.6 | 297.1 | 1.2 | 114.8 | 92.8 | 2.6 | 712.3 | 273.7 | |
*Values have been adjusted to one decimal when possible.
†All values have been calculated according to the method applied in our study taking the original data from the following sources: C. glutamicum (8), E. coli (15), B. subtilis (21, 26), D. radiodurans (25), P. fluorescens (21), V. cholerae (27), and V. fischeri (27).
‡Data from chromosomal mutations.
§Fold increase [MMR-deficient versus wild-type (wt) strain mutation rates].
ǁBlank spaces: No data available.