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. 2020 Feb 12;6(7):eaay1502. doi: 10.1126/sciadv.aay1502

Fig. 4. Adolescent female mice carrying the FAAH SNP display a preference for THC.

Fig. 4

(A) Experimental and developmental timeline for THC CPP protocol in adolescent and adult mice. (B) Adolescent female FAAHC/C mice show significantly lower preference for the THC-paired chamber on the test day compared to the baseline test (paired t test, t15 = 2.782, *P < 0.05, n = 16), while adolescent female FAAHC/A mice show significantly higher preference for the THC-paired chamber on the test day compared to the baseline test (paired t test, t13 = 4.183, **P < 0.01, n = 14). (C) Adolescent female FAAHC/A mice show a significantly higher difference score than adolescent female FAAHC/C mice (unpaired t test, t28 = 4.82, ***P < 0.001, FAAHC/C: n = 16; FAAHC/A: n = 14). (D) Adult female FAAHC/C mice and adult female FAAHC/A mice show no change in preference for the THC-paired chamber on the test day compared to the baseline test (FAAHC/C: paired t test, t14 = 0.9102, P = 0.3781, n = 15; FAAHC/A: paired t test, t19 = 1.316, P = 0.2037, n = 20). (E) Adult female FAAHC/A mice show similar difference scores compared to adult female FAAHC/C mice (unpaired t test, t33 = 1.55, P = 0.1306, FAAHC/C: n = 15; FAAHC/A: n = 20).