Table 3. Quality attributes of different Aceclofenac fast dispersible tablet formulations at different compressional pressures.
Test parameters | FA | FB | FC | FD | FE | FF |
---|---|---|---|---|---|---|
Weight (mg) | 204.1 ± 1.912 | 212.1 ± 1.790 | 207.4 ± 1.955 | 214.2 ± 2.097 | 204.3 ± 2.311 | 212.2 ± 2.529 |
Diameter (mm) | 8.468 ± 0.007 | 8.482 ± 0.010 | 8.49 ± 0.007 | 8.47 ± 0.006 | 8.47 ± 0.021 | 8.47 ± 0.014 |
Thickness (mm) | 2.72 ± 0.055 | 2.76 ± 0.047 | 2.72 ± 0.081 | 2. 77 ± 0.062 | 2.75 ± 0.087 | 2.73 ± 0.086 |
Hardness (N) | 33.58 ± 8.00 | 35.40 ± 6.93 | 34.61 ± 10.46 | 40.68 ± 9.90 | 53.42 ± 11.80 | 43.99 ± 6.25 |
Tensile strength (MPa) | 0.932 ± 0.239 | 0.9628 ± 0.203 | 0.958 ± 0.311 | 1.108 ± 0.292 | 1.468 ± 0.362 | 1.213 ± 0.207 |
Relative density (g/cm3) | 0.93 ± 0.01 | 0.95 ± 0.01 | 0.92± 0.02 | 0.93±0.02 | 0.92 ± 0.03 | 0.92 ± 0.02 |
Friability (%) | 0.50 | 0.68 | 0.30 | 0.32 | 0.34 | 0.29 |
Disintegration time (sec) | 18 | 21 | 40 | 36 | 45 | 40 |
Assay (%) | 99.95 ± 1.34 | 100.10 ± 0.68 | 99.63 ± 0.48 | 100.58 ±1.68 | 98.63 ± 0.80 | 99.56 ± 1.23 |
Dissolution (%) | 99.42 ± 0.52 | 100.38 ± 0.71 | 99.05 ± 0.90 | 100.35 ± 0.77 | 99.10 ± 1.04 | 100.10 ± 1.44 |