Table 1. Results for 19 identified NSCLC risk loci from the GWAS meta-analysis.
| Variants | CytoBand a | Pos. b | Gene | Phenotype | Effect allele | Reference allele | EAF | OR (95%CI) | P | Het P-value |
|---|---|---|---|---|---|---|---|---|---|---|
| Novel associations | ||||||||||
| rs3769821 | 2q33.1 | 202123430 | CASP8 | NSCLC | C | T | 0·321 | 1·08 (1·05-1·11) | 4·45E-08 | 5·99E-02 |
| rs2293607 | 3q26.2 | 169482335 | MYNN | NSCLC | T | C | 0·596 | 1·10 (1 ·06-1·13) | 1·82E-10 | 1·08E-01 |
| rs1200399 | 14q13.1 | 35293185 | B1Z1A | NSCLC | C | T | 0·405 | 1·11 (1·07-1·15) | 3·05E-09 | 6·32E-01 |
| rs17038564 | 2p14 | 65496058 | AFTPH | LUAD | G | A | 0·161 | 1·15 (1·10-1·21) | 1·87E-08 | 8·83E-01 |
| rs35201538 | 9p13.3 | 33422488 | AQP3 | LUAD | C | CT | 0·676 | 1·10 (1 ·06-1·13) | 1·99E-08 | 1·84E-01 |
| rs4573350 | 9q33.2 | 124955115 | DAB21P | LUSC | T | C | 0·505 | 1·13 (1·09-1·18) | 3·23E-09 | 4·01E-03 |
| Previously reported associations | ||||||||||
| rs11375254 | 3q28 | 189343242 | TP63 | NSCLC | T | TA | 0·525 | 1·13 (1·10-1·16) | 1·35E-20 | 7·28E-04 |
| rs13167280 | 5p15.33 | 1280477 | TERT | NSCLC | A | G | 0·170 | 1·24 (1·19-1·28) | 4·59E-32 | 4·83E-02 |
| rs1853837 | 6p21.1 | 41497035 | FOXP4 | NSCLC | A | C | 0·258 | 1·12 (1·08-1·15) | 1·21E-10 | 1·20E-02 |
| rs2517873 | 6p22.1 | 29875992 | MHC | NSCLC | A | G | 0·145 | 1·16 (1·11-1·21) | 4·60E-11 | 6·46E-01 |
| rs5879422 | 6q22.1 | 117784658 | DCBLD1 | NSCLC | T | TTG | 0·510 | 1·08 (1·05-1·11) | 4·36E-09 | 7·60E-01 |
| rs4236709 | 8p12 | 32410110 | NRG1 | NSCLC | G | A | 0·198 | 1·12 (1·09-1·16) | 1·11E-12 | 1·58E-01 |
| rs10429489 | 9p21.3 | 21787521 | CDKN2A | NSCLC | A | G | 0·195 | 1·11 (1·08-1·15) | 6·92E-10 | 7·44E-01 |
| rs12265047 | 10q25.2 | 114487925 | VTI1A | NSCLC | G | A | 0·243 | 1·13 (1·09-1·17) | 7·50E-10 | 6·42E-01 |
| rs55768116 | 11q23.3 | 118108331 | MPZL3 | NSCLC | C | A | 0·489 | 1·10 (1 ·07-1·13) | 2·23E-13 | 6·52E-01 |
| rs77468143 | 15q21.1 | 49376624 | SECISBP2L | LUAD | T | G | 0·767 | 1·14 (1·10-1·18) | 7·48E-12 | 3·30E-01 |
| rs55781567 | 15q25.1 | 78857986 | CHRNA5 | NSCLC | G | C | 0·320 | 1·27 (1·23-1·31) | 8·44E-44 | 3·07E-03 |
| rs200595745 | 17q24.2 | 65915289 | BPTF | NSCLC | A | AAATAATAAT | 0·430 | 1·09 (1·06-1·12) | 2·37E-09 | 8·65E-02 |
| rs56113850 | 19q13.2 | 41353107 | CYP2A6 | NSCLC | C | T | 0·487 | 1·09 (1 ·06-1·12) | 2·69E-09 | 1·44E-02 |
NSCLC: non-small cell lung cancer; LUAD: lung adenocarcinoma; LUSC: lung squamous cell carcinoma; EAF, effect allele frequency; OR, odds (log-additive) ratio; 95% CI, 95% confidence interval.
a
Cytogenic band where the varient is positioned
b
Chromosome position, hg19/GRCh37 build. Cochran’s Q test was used to test for heterogeneity in SNP effort sizes across studies (Het P-value)