Table 2. Esophageal pressure topography characteristics in patients with type-3 achalasia divided by chronic daily opioid exposure into idiopathic (IA3) and opioid-induced (OA3) subgroups.
The data are shown as median and interquartile range and all pressures are in mmHg.
| Esophageal Pressure Topography Characteristics | |||
|---|---|---|---|
| Pressure Metrics | IA3 (N=26) |
OA3 (N=24) |
P value |
| Integrated Relaxation Pressure | 28 (23, 38) | 29 (22, 38) | 0.7 |
| Deglutitive Nadir Pressure | 26 (17, 33) | 22 (18, 27) | 0.2 |
| Intrabolus Pressure | 25 (20, 33) | 25 (20, 30) | 0.9 |
| Distal Contractile Integral (mmHg.s.cm) | 1894 (1283,5795) | 3075 (1098,5575) | 0.7 |
| Distal Latency (s) | 4.3 (3.7, 5) | 4 (3.5,4.4) | 0.1 |
| Contraction Front Velocity (cm/s) | 9 (8, 9) | 9 (8,9) | 0.5 |
| Basal LES Expiratory Pressure | 35 (26, 51) | 31 (26, 45) | 0.3 |
| Basal Gastric Pressure | 9 (7, 11) | 10 (7, 14) | 0.5 |
| Basal Esophageal Pressure | 5 (2, 8) | 4 (0, 9) | 0.4 |
| Frequency Pressure Pattern | |||
| Failed Peristalsis | 0 (0, 30) | 0 (0, 20) | 1.0 |
| Pan-Pressurization | 0 (0, 30) | 0 (0, 10) | 1.0 |
| Premature Contraction | 50 (20, 90) | 80 (60, 90) | 0.3 |
| Rapid Contraction | 40 (20, 80) | 50 (20, 70) | 0.5 |